Role of Neuropeptides in Regulating the Secretion of Growth Hormone and Prolactin

神经肽在调节生长激素和催乳素分泌中的作用

• 批准号: 01570643
• 负责人: KATO Yuzuru
• 金额: $ 0.38万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570643/
• 关键词: Growth hormone; Prolactin; VIP; Serotonin; Galanin; Somatostatin; Neuropeptide; Pituitary tumor; 薬物療法; ド-パミン; オピオイドペプチド; α受容体

The secretion of Growth Hormone (GH) and prolactin (PRL) from the pituitary is regulated by a variety of hypothalamic factors, which are mostly neuropeptides and biogenic amines. We found that GH and PRL secretion induced by serotonin is mediated by hypothalamic GRF and VIP. Galanin stimulates both GH and PRL secretion in the rat. We found that alpha-adrenergic and opioidergic mechanisms are involved in PRL release induced by galanin. Furthermore, the interaction of galanin with serotonin in PRL secretion was also demonstrated. GH secretion induced by galanin is mediated by hypothalamic GRF. On the other hand, PRL and GH secretion is inhibited by endogenous dopamine and somatostatin. GRP stimulates both dopamine and somatostatin release from the hypothalamus. These findings indicate an important and complicated role of neuropeptides in regulating pituitary hormones and suggest a possible therapeutic use of a potent and long-actinf analogue of such neuropeptides in cosistently modulating the function of pituitary tumors.

垂体分泌生长激素（GH）和催乳素（PRL）受多种下丘脑因子的调控，这些因子主要是神经肽和生物胺。我们发现血清素诱导的GH和PRL分泌受下丘脑GRF和VIP的介导。甘丙肽刺激大鼠生长激素和PRL的分泌。我们发现丙氨酸诱导的PRL释放涉及α -肾上腺素能和阿片能机制。此外，还证实了丙氨酸与血清素在PRL分泌中的相互作用。甘丙肽诱导生长激素分泌是由下丘脑GRF介导的。另一方面，PRL和GH的分泌受到内源性多巴胺和生长抑素的抑制。GRP刺激多巴胺和生长抑素从下丘脑释放。这些发现表明神经肽在调节垂体激素方面具有重要而复杂的作用，并提示在持续调节垂体肿瘤功能方面，这种神经肽的有效和长效类似物可能具有治疗用途。

项目成果

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Hattori, N.、Kato, Y. 等人：“通过高灵敏酶免疫测定法测量正常受试者和葡萄糖不耐症和肢端肥大症患者的生长激素对口服葡萄糖负荷的反应。”

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Koshiyama,H.et al.: "Galanin interacts with serotonin in stimulating prolactin secretion in the rat" Journal of Neuroendocrinology. 2. 217-220 (1990)

Koshiyama, H.等人：“甘丙肽与血清素相互作用，刺激大鼠催乳素分泌”《神经内分泌学杂志》。