Experimental Study on Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia

本研究的目的是明确先天性横隔疝所致肺发育不良的病理特点。将胎兔在宫内进行手术，孕期结束后建立先天性膈疝模型。Ⅱ组为硝普芬治疗组。母兔在妊娠期用硝苯醚(NIP；1000、2000、3000ppm)饲养。结果1)肺重量：I组低水平，II组正常；2)肺组织磷脂：II组严重低水平，I组低水平；3)光镜下：I组仅见肺不张，II组肺不张伴肺气肿，肺泡成熟明显迟缓。

The purpose of this study is to make clear the pathological characteristics of hypoplastic lung in congenital diaphragmatic hernia.Two groups were made.Group I was "operation models". Fetal rabbits were operated in utero, and congenital diaphragmatic hernia models were obtained after gestational period.Group II was "Nitrofen treated group". Maternal rabbits were bred with nitrofen (NIP ; 1000, 2000, 3000 ppm) in their gestational period. (But only "non-CDH models with lung damage were obtained)RESULTS ; compared with "Control Group"1) Lung weight : low leveled in, Group I, and normo leveled in Group II.2) Phospholipids in lung tissue : Severely low leveled in Group II, and low leveled in Group I.3) Microscopical findings : Only atelectasis was found in Group I, but in Group II atelectasis with emphysema were found and the retardation of the alveolar maturation were remarked.