权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Experimental Study on Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia

先天性膈疝肺发育不全的实验研究

基本信息

批准号：
01570717
负责人：
SASAKI Shingi
金额：
$ 1.34万
依托单位：
Nagoya City Univeristy Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570717/
关键词：
congenital diaphragmatic hernia experimental fetal surgery Nitrofen (NIP)lung hypoplasia phospholipids in lung tissue dysplasia of diaphragma 実験脂仔手術家兎胎仔手術 Nitrofen

项目摘要

The purpose of this study is to make clear the pathological characteristics of hypoplastic lung in congenital diaphragmatic hernia.Two groups were made.Group I was "operation models". Fetal rabbits were operated in utero, and congenital diaphragmatic hernia models were obtained after gestational period.Group II was "Nitrofen treated group". Maternal rabbits were bred with nitrofen (NIP ; 1000, 2000, 3000 ppm) in their gestational period. (But only "non-CDH models with lung damage were obtained)RESULTS ; compared with "Control Group"1) Lung weight : low leveled in, Group I, and normo leveled in Group II.2) Phospholipids in lung tissue : Severely low leveled in Group II, and low leveled in Group I.3) Microscopical findings : Only atelectasis was found in Group I, but in Group II atelectasis with emphysema were found and the retardation of the alveolar maturation were remarked.

为了解先天性腹股沟疝肺发育不良的病理特点，本研究分为两组，Ⅰ组为“手术模型”;采用胎兔宫内手术，孕后期制作先天性腹股沟疝模型。母兔在妊娠期用除草醚（NIP ; 1000，2000，3000 ppm）饲养。(But结果：与“对照组“相比：1）肺重量：I组为低水平，II组为正常水平。2）肺组织中磷脂：II组为严重低水平，I组为低水平。3）显微镜下所见：I组仅出现肺不张，而II组则出现肺不张伴肺气肿，肺泡发育迟缓。