The Experimental Allotransplantation of Trachea and Bronchus in dogs

犬同种异体气管、支气管移植实验

• 批准号: 01570794
• 负责人: OHATA Masaaki
• 金额: $ 0.77万
• 依托单位: 2nd Department of Surgery. Nihon University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570794/
• 关键词: allotransplantation; trachea transplantation; omentopexy; bloody supply; 気管・気管支同種移植; 大網被覆

There still remain many problems to be solved on allotransplantation of trachea. The blood supply to the graft is one of the most important factors for its survival. This study was carried out to evaluate the effects of omentopexy that will be more increase of blood supply to the graft.Twelve dogs were used for this experiment of allotransplantation of trachea. Under intravenous general anesthesia, the cervical trachea in the donor dog was exposed and 5 segments of tracheal cartslage were excised, and then these grafts were transplanted at the same portion of the cervical trachea in the recipient dog. After the allotransplantation, the omental pedicle was transplanted around the graft, to get the effective blood supply. The canines were divided into two groups: group A; good blood supply in omentum (n=6) and group B; poor supply in omentum (n=6)White coating was observed inside the graft in all dogs with bronchofiberscopy. The dogs of group A, however, had survived longer than the dogs of group B. The mean survival days of group A and B were 34.6 * 6.80 days and 18.4 * 6.47 days, respectively.These results suggest that the blood supply to the allograft of trachea by omentopexy is important factor for the extension of its survival time.

同种异体气管移植仍有许多问题有待解决。移植物的血液供应是其存活的最重要因素之一。本研究的目的是评价网膜切开术对移植物供血量增加的影响。本实验采用12只狗进行同种异体气管移植实验。在静脉全身麻醉下，暴露供犬颈部气管，切除5段气管软骨，将这些移植物移植到受犬颈部气管的同一部位。同种异体移植后，在移植物周围移植大网膜蒂，以获得有效的血液供应。犬分为两组：A组；网膜血供良好（n=6）和B组；大网膜供血不足（n=6）所有犬经纤维支气管镜检查均可见移植物内白色涂层。A、B组的平均生存天数分别为34.6 * 6.80天和18.4 * 6.47天。提示经网膜固定术的同种异体气管移植物的血供是延长其存活时间的重要因素。

项目成果

長坂 不二夫,大畑 正昭,飯田 守,大森 一光,北村 一雄,中村 士郎,小笠原 弘二,並木 義夫,村松 喬,西村 理,瀬杜 幸安: "気管同種移植の実験的検討 -特に有茎大綱弁の効果について-" 日本呼吸器外科学会雑誌. 5. 378- (1991)

Fujio Nagasaka、Masaaki Ohata、Mamoru Iida、Kazumitsu Omori、Kazuo Kitamura、Shiro Nakamura、Koji Ogasawara、Yoshio Namiki、Takashi Muramatsu、Osamu Nishimura、Yukinasu Seto：“气管同种异体移植的实验研究 - 特别是带蒂口瓣膜”关于有效性 - ”日本呼吸外科学会杂志。5. 378- (1991)

Toledo-Pereyra, L.H. and Condie, R.M.: "Lung transplantation. Hypothermic storage for 24 hours in a colloid hyperosmolar solution." J. Thorac. Cardiovasc. Surg.76. 846 (1978)

Toledo-Pereyra, L.H. 和 Condie, R.M.：“肺移植。在胶体高渗溶液中低温保存 24 小时。”

長坂 不二夫,大畑 正昭,飯田 守,大森 一光,北村 一雄,中村 士郎,小笠原 弘二,並木 義夫,村松 高,西村 理,瀬在 幸安: "気管同種移植の実験的検討 ー特に有茎大綱の効果についてー" 日本呼吸器外科学会雑誌. 5. 378 (1991)

Fujio Nagasaka、Masaaki Ohata、Mamoru Iida、Kazumitsu Omori、Kazuo Kitamura、Shiro Nakamura、Koji Ogasawara、Yoshio Namiki、Takashi Muramatsu、Osamu Nishimura、Koyasu Sezai：《气管同种异体移植的实验研究 - 特别是带蒂鸵鸟的效果》关于《杂志》日本呼吸外科学会。 5. 378 (1991)

Morgan, E., Lima, O., Goldberg, M., et al.: "Successful revascularization of totally ischemic bronchial autografts with omental pedicle flaps in dos." J. Thorac. Cardiovasc. Surg.84. 204 (1982)

Morgan, E.、Lima, O.、Goldberg, M. 等人：“用大网膜蒂皮瓣成功实现完全缺血性自体支气管血运重建。”

Balderman, S.C. and Weinblatt, G.: "Tracheal sutograft revascularization." J. Thorac. Cardiovasc. Surg.94. 434 (1987)

Balderman, S.C. 和 Weinblatt, G.：“气管移植血运重建。”