The Experimental Allotransplantation of Trachea and Bronchus in dogs

同种异体气管移植仍有许多问题需要解决。移植物的血液供应是移植物存活的最重要因素之一。本研究通过12只狗的同种异体气管移植实验，评价了增加移植物血供的大网膜固定术的效果。在静脉全身麻醉下，显露供体犬的颈部气管，切除5段气管段，然后将这些移植物移植到受体犬的同一部位。同种异体移植后，在移植物周围移植带蒂大网膜蒂，以获得有效的血供。将犬分为两组：A组，大网膜血供良好组(n=6)；B组，大网膜血供差组(n=6)。纤维支气管镜检查均见移植物内有白色涂层。A组存活时间明显长于B组，平均存活天数分别为34.6±6.80天和18.4±6.47天，提示同种异体气管大网膜固定术供血是延长存活时间的重要因素。

There still remain many problems to be solved on allotransplantation of trachea. The blood supply to the graft is one of the most important factors for its survival. This study was carried out to evaluate the effects of omentopexy that will be more increase of blood supply to the graft.Twelve dogs were used for this experiment of allotransplantation of trachea. Under intravenous general anesthesia, the cervical trachea in the donor dog was exposed and 5 segments of tracheal cartslage were excised, and then these grafts were transplanted at the same portion of the cervical trachea in the recipient dog. After the allotransplantation, the omental pedicle was transplanted around the graft, to get the effective blood supply. The canines were divided into two groups: group A; good blood supply in omentum (n=6) and group B; poor supply in omentum (n=6)White coating was observed inside the graft in all dogs with bronchofiberscopy. The dogs of group A, however, had survived longer than the dogs of group B. The mean survival days of group A and B were 34.6 * 6.80 days and 18.4 * 6.47 days, respectively.These results suggest that the blood supply to the allograft of trachea by omentopexy is important factor for the extension of its survival time.