Clinical and Experimental Study on Malignant Glaucoma

1)恶性青光眼的临床研究：分析了2例激光虹膜切开术后，3例视网膜中央静脉阻塞，3例原田病，2例葡萄膜渗出，1例多灶性后部色素上皮病，1例颈动脉海绵窦瘘和8例视网膜脱离手术后表现为青光眼的患者的临床表现和生物计量学值。眼内病变除视网膜脱离外均为女性，除1例Harada病高度近视眼外，其余均表现为视轴长度短于正常值。在所有病例中，散瞳-睫状肌麻痹治疗均有效，但在某些病例中不足以控制眼内压。（2）前列腺素E_2的实验研究：局部应用前列腺素E_2（PEG_2）可增加睫状体血流量，使睫状突明显肿胀。应用PEG_2后眼压立即升高，但前房深度仅在应用高剂量PEG_2时才增加。未预先应用毛果芸香碱对眼压和前房深度的变化没有影响。3）根据这些临床和实验结果，我们提出了恶性青光眼的机制和治疗方案。

1) Clinical Study of Patients with Malignant Glaucoma :Clinical findings and biometric values of two cases after laser iridotomy, 3 cases with central retinal vein occlusion, 3 cases with Harada's disease, 2 cases with uveal efflusion, one case of multifocal posterior pigment eqitheliopathy, one case with carotid cavernous fistula and 8 cases after the retinal detachment surgery, which showed malignat glaucoma, were analysed. All cases with intraocular pathology except for the cases with retinal detachment were female and all cases but one with high myopia of Harada's disease showed optic axis length shorter than the normal value. In all cases mydriatics-cycloplegic therapy was effective, but in some cases not enough to control intraocular pressure. The effect of iridotomy was doubtful, but the effect of pupillary block could not be excluded in some cases.2) Experimental Studies with Prostaglandne E _2 In Rabbits :Topical application of prostaglandin E_2 (PEG_2) increased the blood flow in the ciliary body and showed marked sweelling of the ciliary processes. Intraocular pressure incresed immediately after the application of PEG_2 , but the anteriol chamber depth increased only with an application of high dosage of PEG_2 . No prior application of pilocarpine had effect on these changes in intraocular pressure and anterior chamber depth.3) From these clinical and experimental results we proposed a schema on the mechanism and therapy of malignant glaucoma.