The catalact and microphalmia Rats onset of animal model Breeding and genetical analys with inherited retinal dystrophy

遗传性视网膜营养不良动物模型的选育和遗传分析

• 批准号: 01580047
• 负责人: YAGYU Sigeru
• 金额: $ 1.09万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01580047/
• 关键词: Retial Dystrophy; Catalact; microphalmia; Congenic strain; RCS; ガラクト-ス; サッカロ-ス; RCS; n; 網膜変性; 白内障・小眼球症モデル動物; 眼底写真; N-

The Retinal Dystrophy Rats(RCS/N-rdy/rdy-p/p, RCS/N-rdy/rdy-p/+) were tested for fluorescent fundus angiography.This test result in retinal caplallary blood vessel were very thin and not crossing. The Retinal caplallary blood vessel dye-leakage and thin appeared in Black Hooded Retinal Dystrophy Rats(RCS/N-rdy/rdy-p/+). The outer nuclear layer is completely lost, but the inner nuclear layer isn't well preserved at 20 Weeks Retinal Dystrophy Rats(RCS/N-rdy/rdy-p/p, RCS/N-rdy/rdy -P/+). A higher incidence of mature cataract in pinkeye(RCS/N-rdy/rdy-p/p) Rats (23%) as compared with black-eyed(RCS/N-rdy/rdy-p/+) Rats (3%). We breeding high incidence of mature cataract in pinkeye Rats (50%) as compared with black-eyed Rats (o%).Genetical studies revealed that the trait was transmitted recessively by simple facter.

对视网膜营养不良大鼠(RCS/N-rdy/rdy-p/p，RCS/N-rdy/rdy-p/+)进行了眼底荧光血管造影检查。黑帽视网膜营养不良大鼠(RCS/N-Rdy/Rdy-p/+)视网膜毛细血管渗漏、变薄。20周龄视网膜营养不良大鼠(RCS/N-Rdy/rdy-p/p，RCS/N-Rdy/rdy-P/+)外核层完全消失，内核层保存不完整。红眼(RCS/N-rdy/rdy-p/p)大鼠成熟性白内障的发生率(23%)高于黑眼(RCS/N-rdy/rdy-p/+)大鼠(3%)。我们培育的红眼大鼠的成熟性白内障发生率(50%)高于黑眼大鼠(0%)。遗传学研究表明，该性状是由单因素隐性遗传的。

项目成果

柳生茂: "遺伝性網膜変性症ラットにおける眼底検査および組織学的検討" 藤田学園医学会.

Shigeru Yagyu：“遗传性视网膜变性大鼠的眼底检查和组织学检查”藤田学园医学会。

Sigeru. yagyu: "The cataract and microphalmia Rats onset of animal with inherited retinal dystrophy" The Journal Experimental animal Technology. 27, No. 2. (1992)

西格鲁。

柳生 茂: "遺伝性網膜変性症ラット(RCS/Nーrdy)3系統における白内障・小眼球症発症動物の繁殖育成" 実験動物技術. 27. (1992)

Shigeru Yagyu：“遗传性视网膜变性（RCS/N-rdy）三种品系大鼠白内障和小眼球动物的饲养和饲养”实验动物技术27。（1992）。

柳生 茂: "遺伝性網膜変性症ラット3系統における眼血管の樹脂鋳型標本及びトリプシン消化標本を用いた網膜血管の立体的構築" 藤田学園医学会誌. (1992)

Shigeru Yagyu：“使用树脂铸型标本和胰蛋白酶消化的三种遗传性视网膜变性大鼠品系的眼血管标本进行视网膜血管的三维构建”Fujita Gakuen Medical Society Journal（1992）。

柳生 茂: "各種近交系ラットにおける眼底検査" 実験動物技術. 27. (1992)

Shigeru Yagyu：“各种近交系大鼠的眼底检查”实验动物技术27。（1992）