Efficacy of Kanpo Therapy in Ulcerative Colitis

溃疡性结肠炎（UC）被认为具有免疫异常，主要采用水杨基偶氮磺胺吡啶（SASP）和皮质类固醇激素（CS）治疗。本研究探讨中药赛雷托对UC患者化学发光反应（CL）免疫缺陷及培养T淋巴细胞功能的改善作用。三分之一的活动期UC患者通过Saireito联合CS或SASP得到改善。与健康对照组相比，UC组CL活性升高。p. o.给药后CL活性降低。活动性UC患者培养的T细胞株CD4阳性标记物表达，CD3抗体应答率高于对照组。在体外实验中，沙雷头能有效抑制细胞的增殖反应。UC患者建立的T细胞株中TNF的产生高于正常粘膜细胞株。与皮质类固醇作用类似，Saireito溶液也能抑制TNF的产生。给药后，Saireito能抑制中性粒细胞CL活性。对T细胞淋巴细胞功能的研究提示Saireito可能对免疫功能有一定影响。基于这些结果，我们认为Saireito治疗UC不仅可以减少CS或SASP的剂量，还可以改善UC的免疫缺陷。

Ulcerative colitis (UC) is supposed to have the immunological abnormalities and is treated mainly with salicyl-azosulfapyridine (SASP) and corricosteroid hormone (CS). We investigated the effect of Saireito (Chinese traditional medicine) on improving the immunological deficiency of the chemiluminescent response (CL) and cultured T lymphocyte function derived from UC patient.One third patient with active UC stage were improved by Saireito therapy combined with CS or SASP. The activity of CL was increased in UC group compared with healthy control group. The CL activities were decreased after p. o. administration of Saireito.The cultured T cell line derived from active UC patients were expressed CD4 positive marker and more responded CD3 antibody compared with control group. Saireitou was efficient to suppress the proliferative response in vitro. The production of TNF in established T cell line from UC patient was higher than the cell line from normal mucosa. The production of TNF was also suppressed by Saireito solution similar to corticosteroid effect.Saireito suppressed the CL activities of neutrophils after p. o. administration. The study on T cell lymmphocyte function suggested the possibility that Saireito has some influence on immune function. On the basis of these results, we suggest that Saireito might be able to use treatment of UC not only for reducing the dose of CS or SASP but improving the immune deficiency of UC.