Studies of the mechanism for prevention of atherosclerosis with polyunsaturated fatty acids

多不饱和脂肪酸预防动脉粥样硬化的机制研究

• 批准号: 02045040
• 负责人: GOTO Yuichiro
• 金额: $ 2.69万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02045040/
• 关键词: PUFA; Coronary sclerosis; Lipid metabolism; African green monkey; Lipoprotein composition; composition; PTCA; Lipid transfer protein; Lp(a); 飽和脂肪酸; リポ蛋白代謝; 虚血性心疾患

We investigated effects of polyunsaturated fatty acids (PUFA) on lipoprotein matabolism and atherosclerosis both in humans and african green monkeys for making clear the differences in response to these agents between both subjects. African green monkeys were fed diets containing 11 % (by weight) fish oil as PUFA or lard as saturated fatty acid (SFA) with 0.75 mg cholestero1/Kcal in one experiment, and linoleic as PUFA, oleic acid as monounsaturated faccy acid (MUFA) or palm oil as SFA in an another experiment. Total plasma cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations were significantly lower for the fish oil group compared to the lard group. HDL-C concentrations were 30 % lower for the fish oil group also. Almost the same results obtained in the other experiment, with the exception that no change in HDL-C concentrations of MUFA diet group. LDL-particle size were decreased in the fish oil group. Atherosclerotic lesion of Coronary artery, the thoratic aorta, common carotid arteries was less for the fish oil group.The patients with ischemic heart disease or hyperlipoproteinemia administered 0.9-2.7 g/day, resulting that TC, LDL-C and TG concentrations were decreased but HDL-C concentrations were not constant. LDL particle size were decreased after EPA. The effect of EPA on restenosis after percutaneous transluminal coronary angioplasty were evaluated by comparing the patient groups with and without EPA, resulting no remarkable changes in restenosis rate between both groups.

我们研究了多不饱和脂肪酸(PUFA)对人类和非洲绿猴脂蛋白代谢和动脉粥样硬化的影响，以明确这两个受试者对这些物质的反应差异。在一个实验中，非洲绿猴饲喂含有11%(按重量计)的鱼油作为多不饱和脂肪酸或猪油作为饱和脂肪酸(SFA)，胆固醇为0.75毫克/千卡，亚油酸作为多不饱和脂肪酸，油酸作为单不饱和脂肪酸(MUFA)或棕榈油作为饱和脂肪酸。与猪油组相比，鱼油组的血浆总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)浓度显著降低。鱼油组的高密度脂蛋白胆固醇浓度也降低了30%。除MUFA饲料组的高密度脂蛋白胆固醇浓度无明显变化外，其余实验结果基本相同。鱼油组的低密度脂蛋白颗粒变小。鱼油组冠状动脉、胸主动脉、颈总动脉粥样硬化病变较轻，缺血性心脏病或高脂蛋白血症患者每日服用0.9~2.7g，可降低TC、LDL-C和TG浓度，但HDLc浓度不稳定。EPA后低密度脂蛋白颗粒变小。通过比较使用和不使用EPA的患者组，评价EPA对经皮冠状动脉腔内成形术后再狭窄的影响，结果显示两组再狭窄率无显著差异。

项目成果

Y. Goto, H. Tamachi, Y. Shiina, Y. Fuusegawa, K. Kanabushi, Y. Kuribayashi: "Effect of EPA on LTP activity" The Japan & US Cooperative Medical Science Program, Panel Meeting of the Malnutrition (1991, Report). 49-56 (1991)

Y. Goto、H. Tamachi、Y. Shiina、Y. Fuusekawa、K. Kanabushi、Y. Kuribayashi：“EPA 对 LTP 活性的影响” 日本

五島 雄一郎,玉地 寛光,椎名 豊,中山 浩二,高橋 潔,金渕 一雄,大滝 誠: "3.不飽和脂肪酸の栄養学的意義.EPA投与のPTCA後再狭窄に及ぼす影響" 平成4年度日米医学協力計画・栄養異状専門部会報告書.

Yuichiro Goto、Hiromitsu Tamachi、Yutaka Shiina、Koji Nakayama、Kiyoshi Takahashi、Kazuo Kanebuchi、Makoto Otaki：“3.不饱和脂肪酸的营养意义。EPA给药对PTCA后再狭窄的影响”1992年。美国医疗合作计划特别报告营养异常委员会。

John S. Parks: Medical Tribune. Review of Polyunsaturated fatty acids effects on Lipoproteins nad Heart disease in Human Being, 35-48 (1991)

约翰·S·帕克斯：《医学论坛报》。

Lawrence L. Rudel: Medical Tribune. Mechanisms of Dietary Fat included alterations of plasma lipoproteins and Atherosclerosis., 45-59 (1991)

劳伦斯·L·鲁德尔：《医学论坛报》。

Parks.JS.Sawyer.JK.Bullock.BC.Rudel.LL: "Effcct of Dietary Fish Oil on Coronary Artery and Aortic Atherosclcrosis in African Green Monkeys" Arteriosclerosis. 10. 1102-1112 (1990)

Parks.JS.Sawyer.JK.Bullock.BC.Rudel.LL：“膳食鱼油对非洲绿猴冠状动脉和主动脉粥样硬化的影响”动脉硬化。