Co-operative Research on Boron-neutron capture therapy for various Malignant tumors

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Boron neutron capture therapy (BNCT) in Japan has been applied to treating more than 146 brain tumor patients since 1968 by Hatanaka and collaborators utilizing mercaptoundecaphydrododecaborate (BSH) at reactors of Musashi Institute of Technology, Kyoto University Reactor (KUR) and Japan Reactor-2 of Japan Atomic Energy Research Institute (JRR-2). BNCT is now being tried also by Oda of Kyoto University (9 cases) and by Nakagawa of Tokushima University (7 cases) at KUR since 1991. It has been also tried by Mishima (Kobe University) on 12 skin melanoma patients.Brain-stem tumors and skull base tumors, which have posed difficult problems in neurosurgery are being treated with the aid of heavy water and multiportal irradiation. Hatanaka has been also proving good effect ob BNCT upon giant cerebral arteriovenous malformation (AVM).For cancer of liver and abdominal viscerae, antibody to the tumor specific antigen has been considered a good carrier of boron-10 (Yanagie, Takahashi, Tokyo University).An encouraging result was obtained in animal experiment. Bone cancer have been studied by veterinary surgeons Takeuchi and Kadosawa at Tokyo University by using boronated derivative of porphyrins (BTPP) with satisfactory accumulation in the tumor tissue. BNCT appears to be a good device to treat difficult lesions in the brain and other organs which defy sophisticated modern therapeutic means.