Co-operative Research on Boron-neutron capture therapy for various Malignant tumors

自1968年以来，日本的硼中子俘获疗法（BNCT）已被Hatanaka及其合作者应用于武藏工业大学、京都大学反应堆（KUR）和日本原子能研究所（JRR-2）的日本反应堆-2的反应堆中，利用巯基十六氢十二硼酸盐（BSH）治疗了146多名脑肿瘤患者。自1991年以来，京都大学的Oda（9例）和德岛大学的Nakagawa（7例）也在KUR进行BNCT试验。三岛（神户大学）也在12名皮肤黑色素瘤患者身上进行了试验。脑干肿瘤和颅底肿瘤一直是神经外科的难题，目前正利用重水和多门静脉照射治疗脑干肿瘤和颅底肿瘤。Hatanaka也证实了BNCT治疗巨大脑动静脉畸形（AVM）的良好效果。对于肝癌和腹部脏器癌，针对肿瘤特异性抗原的抗体被认为是硼-10的良好载体（Yanagie, Takahashi, Tokyo University）。动物实验取得了令人鼓舞的结果。东京大学的兽医Takeuchi和Kadosawa用硼化卟啉衍生物（BTPP）在肿瘤组织中进行了骨癌研究。BNCT似乎是一种很好的设备来治疗大脑和其他器官的疑难病变，这是复杂的现代治疗手段所无法做到的。

Boron neutron capture therapy (BNCT) in Japan has been applied to treating more than 146 brain tumor patients since 1968 by Hatanaka and collaborators utilizing mercaptoundecaphydrododecaborate (BSH) at reactors of Musashi Institute of Technology, Kyoto University Reactor (KUR) and Japan Reactor-2 of Japan Atomic Energy Research Institute (JRR-2). BNCT is now being tried also by Oda of Kyoto University (9 cases) and by Nakagawa of Tokushima University (7 cases) at KUR since 1991. It has been also tried by Mishima (Kobe University) on 12 skin melanoma patients.Brain-stem tumors and skull base tumors, which have posed difficult problems in neurosurgery are being treated with the aid of heavy water and multiportal irradiation. Hatanaka has been also proving good effect ob BNCT upon giant cerebral arteriovenous malformation (AVM).For cancer of liver and abdominal viscerae, antibody to the tumor specific antigen has been considered a good carrier of boron-10 (Yanagie, Takahashi, Tokyo University).An encouraging result was obtained in animal experiment. Bone cancer have been studied by veterinary surgeons Takeuchi and Kadosawa at Tokyo University by using boronated derivative of porphyrins (BTPP) with satisfactory accumulation in the tumor tissue. BNCT appears to be a good device to treat difficult lesions in the brain and other organs which defy sophisticated modern therapeutic means.