Tetralogy of Fallot, Cardiac Hypertrophy, Pulmonary Hypertension and Aomalies of Great Vessels in WKY/NCrj Rats

我们解剖检查了269 WKY/NCrj大鼠在三个胎儿和三个新生儿阶段的心脏，肺和大血管。严重的肺动脉瓣增厚存在于16和室间隔缺损覆盖的主动脉在15的90个近期胎儿和10和9，分别在79个新生儿在2-4天的年龄。这些异常同时发生在7个近期胎儿和5个新生儿中（法洛四联症）。55%的胎儿和56%的新生儿存在肺流出道狭窄。肺动脉分支壁异常增厚的胎儿占19%，新生儿占26%，其中大多数没有间隔缺损。约80%的胎儿室间隔中纬肌束与左心室游离壁不连续，而与右心室游离壁不连续;出生后，与两个游离壁不连续。在79名新生儿中，49%的人心脏异常沉重。 ...更多信息 tes.在大约一半的沉重的心脏中，没有间隔缺损或肺动脉瓣和动脉病变。在所有WKY胎儿和新生儿中，有4例双主动脉弓和6例右主动脉弓; 47%的近足月胎儿动脉导管异常小，51%的近足月胎儿主动脉大。本研究检测了WKY大鼠与正常Wistar大鼠（F1）交配的第一代子代78只孕21天胎儿（G21）和83只出生后2天新生儿（A2）。此外，我们在妊娠第19天（G19）检查了6组胎仔：65只Wistar大鼠、111只WKY大鼠、85只Fl、100只Fl x Fl、92只Fl x Wistar和97只Fl x WKY后代。这些结果表明，WKY大鼠的心血管畸形是以常染色体隐性遗传或不完全常染色体显性遗传（不完全显性和可变表达）或多基因遗传。对31只WKY胎儿进行染色体分析，未发现与心血管畸形发展相关的异常。这些大鼠为5至30周龄，体重在105至705克之间。分别在俯卧位或右卧位通过左或右胸骨旁窗将换能器放置在大鼠下方，获得心室、心房、瓣膜和大动脉的二维和M模式视图。超声心动图可用于获得大鼠心脏的解剖学评价和定量测量。少

We examined anatomically the hearts, lungs, and great vessels of 269 WKY/NCrj rats at three fetal and three neonatal stages. Severe pulmonary valve thickening was present in 16 and ventricular septal defects with overriding of the aorta in 15 of the 90 near-term fetuses and in 10 and nine, respectively, of the 79 neonates at 2-4 d of age. These abnormalities occurred together (tetralogy of Fallot) in seven of the near-term fetuses and in five of the neonates. A narrow pulmonary outflow tract was present in 55% of the fetuses and in 56% of the neonates. The wall of the pulmonary arterial branch was abnormally thick in 19% of the fetuses and in 26% of the neonates, most of which did not have septal defects. In about 80% of the fetuses, the middle latitudinal muscle bundle of the ventricular septum was not-continuous with the left ventricular free wall, but rather with the right ; after birth, it was discontinuous with both free walls. The heart wag abnormally heavy in 49% of the 79 neona … More tes. In about half of the heavy hearts, there were no septal defects or pulmonary valvular and arterial lesions. There were double aortic arches in four and right aortic arches in six of the total WKY fetuses and neonates ; the ductus arteriosus was abnormally small in 47% and the aorta was large in 51% of the nearterm fetuses. This constellation of congenital heart disease is genetic in origin, but altered by hemodynamics late in fetal life.We examined 78 fetuses on d 21 of gestation (G21) and 83 neonates on d 2 after birth (A2), which were first generation offsping of WKY rats mated with normal Wistar rats (Fl). In addition, we examined six groups of fetuses on d 19 of gestation (Gl9) : 65 Wistar rats, 111 WKY rats, 85 Fl, 100 Fl x Fl, 92Fl x Wistar, and 97 Fl x WKY progeny. These results suggest that cardiovascular anomalies of WKY rati are transmitted as autosomal recessive or incomplete autosomal dominant traits with an incomplete penetrance and variable expressivity or as polygenic traits. Chromosomal analysis of 31 WKY fetuses revealed no abberations specifically related to the development of cardiovascular malformations.A high-frequency transducer was used to determine the optimal parameters for visualizing the heart in 40 normal Wistar, 15 SHR, and 10 aorta-banded rats. The rats were 5 to 30 weeks old and weighed between 105 and 705 grams. Two-dimensional and M-mode views of the ventricles, atria, valves, and great arteries were obtained by placing the transducer beneath the rats through the left or right parasternal window in either the prone or the right decubitus positions, respectively. Echocardiography is useful for obtaining anatomical evaluation and quantitative measurements in the hearts of the rats. Less