Development and application of a system for 3-D measurement of biostructures by computational geometry

计算几何生物结构3D测量系统的开发和应用

基本信息

  • 批准号:
    02559004
  • 负责人:
  • 金额:
    $ 5.12万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
  • 财政年份:
    1990
  • 资助国家:
    日本
  • 起止时间:
    1990 至 1991
  • 项目状态:
    已结题

项目摘要

Although the pathological studies deal with 3-dimensional biostructures such as the organs, tissues and cells of man and animals, the actural means of observation is confined to 2-dimensional sectional pictures, The tchniques of stereology, which is based on stochastic geometty, cannot work in most aspects of pathology where one is often unable to assimilate actual biostructures with pertinent geometric models. In view of this, we designed a system by which to perform 3-dimensional measurement of biostructures by computational geometry from structural data in putted from serial sections. We managed to establish algorithms for the following three tasks, in which, the system is ready to application to actual studies.1. Computer-assisted granulometry : This is to obtain information on the number and size distribution of granular biostructures such as the cells, their nuclei or the islets of Langerhans. The computer scans through "sampling bricks, " a 3-dimensional sampling probe constructed in a tissue space containing granules and inputted from serial sections.2. Expression of vascular pattern with the spatial distance distribution : An algorithm was devised to compare the pattern of 3-dimensional architecture with the distribution of distances from randomly positioned points to the structure of interest. The method was applied to the analysis of vasculature in livers with chronic hepatitis and cirrhosis, to quantitatively describe how the vascular arrangement deviates from the norm with the progress of cirrhogenesis.3. Three-dimensional topological analysis : There are features of diseased organs that can be analyzed only in topological terms, such as the form of carchinoma cell nests. This requirement was met by developing an algorithm for computer-aided measurement of topological invariable (1st Betti number). We aere now finding a solution for the three-dimensional thinning of biostructures, which will give us a method to visualize their skeleton.
虽然病理学研究涉及三维生物结构,如人和动物的器官、组织和细胞,但实际观察手段仅限于二维截面图。基于随机几何的体视学技术不能用于病理学的大多数方面,因为人们往往无法将实际生物结构与相关的几何模型同化。有鉴于此,我们设计了一个系统,通过该系统,通过计算几何学,从连续切片的结构数据中获得生物结构的三维测量。我们成功地建立了以下三个任务的算法,其中,系统准备应用于实际研究.计算机辅助粒度测定:这是为了获得颗粒生物结构(如细胞、细胞核或胰岛)的数量和尺寸分布信息。计算机扫描“取样砖“,这是一种三维取样探针,构建在含有颗粒的组织空间中,并从连续切片输入。用空间距离分布表达血管模式:设计了一种算法,将三维结构的模式与从随机定位的点到感兴趣结构的距离分布进行比较。将该方法应用于慢性肝炎和肝硬化患者肝脏血管的分析,定量描述随着肝硬化的进展,肝脏血管排列偏离正常的情况.三维拓扑分析:病变器官的某些特征只能用拓扑术语进行分析,例如癌细胞巢的形式。这一要求是通过开发一种计算机辅助测量拓扑不变量(第一贝蒂数)的算法来满足的。我们现在正在寻找一种解决方案,用于生物结构的三维细化,这将为我们提供一种可视化骨骼的方法。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tamihiko Chiba et al.: "Computerization of serial-section-based granulometry using "sampling bricks. "" Journal of Microscopy.
Tamihiko Chiba 等人:“使用“采样砖”对基于连续截面的粒度测定进行计算机化。
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    0
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斎藤 豊文: "三次元ユ-クリッド距離変換による肝組織連続切片顕微鏡像の解析" 医用電子と生体工学. 30. 257 (1992)
Toyofumi Saito:“使用三维欧几里德距离变换对肝脏组织连续切片的显微图像进行分析”《医疗电子与生物工程》30. 257 (1992)。
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    0
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Toshiki Kikuchi et al.: "Morphometric study on the re-organization of lobular structure of the liver in cirrhogenesis. Parametrization using techniques of computational geometry." Pathology and Clinical Medicine (in Japanese, with English summary).
Toshiki Kikuchi 等人:“肝硬化过程中肝小叶结构重组的形态测量研究。使用计算几何技术进行参数化。”
  • DOI:
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  • 影响因子:
    0
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高橋 徹: "ThreeーD computational geometry:The pattern of vasculature in normal and diseased livers as expressed by the distribution of distance in space." Acta Stereologica. 11. (1992)
Toru Takahashi:“三维计算几何:正常和患病肝脏中的脉管系统以空间距离分布表示。”Acta Stereologica 11。
  • DOI:
  • 发表时间:
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  • 影响因子:
    0
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Takahashi T,Chiba R: "(分担執筆)Research of Pattern Formation (ed.by R.Takaki)" KTKーReidel Publishers/Tokyo, (1991)
Takahashi T、Chiba R:“(贡献者)模式形成研究(R.Takaki 编辑)”KTK-Reidel 出版社/东京,(1991 年)
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    0
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TAKAHASHI Tohru其他文献

TAKAHASHI Tohru的其他文献

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{{ truncateString('TAKAHASHI Tohru', 18)}}的其他基金

Development of a positron source using crystal-amorphous hybrid targets
使用晶体-非晶混合靶材开发正电子源
  • 批准号:
    22540314
  • 财政年份:
    2010
  • 资助金额:
    $ 5.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effect of heavy metal accumulation in sandy tidal flats of Ariake Bay on the shell forming and survival of juvenile short-neck clam.
有明湾沙质滩涂重金属富集对短颈蛤幼体成壳及生存的影响
  • 批准号:
    19580223
  • 财政年份:
    2007
  • 资助金额:
    $ 5.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effect of manganese accumulation on the survival of juvenile short neck clam, Ruditapes philippinarum in the sandy tidal flat of Ariake Bay, Kyushu, Japan.
日本九州有明湾沙质滩涂锰积累对菲律宾蛤仔幼苗生存的影响。
  • 批准号:
    16580162
  • 财政年份:
    2004
  • 资助金额:
    $ 5.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Generation of photon beams by the laser-Compton scattering
通过激光康普顿散射产生光子束
  • 批准号:
    09440107
  • 财政年份:
    1997
  • 资助金额:
    $ 5.12万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
INVESTIGATION INTO CREEP BEHAVIOR IN POLYCRYSTALS OF TITANIUM ALUMINIDE INTERMETALLIC COMPOUNDS
钛铝化物多晶蠕变行为的研究
  • 批准号:
    63550522
  • 财政年份:
    1988
  • 资助金额:
    $ 5.12万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
The Re-organization of Circulation in Lungs with Advanced Hypertensive Arteriopathy and Obstructed Vascular Bed. A Computer-aided Reconstruction of Lung Vasculature in Patients with Congenital Heart Disease
晚期高血压动脉病和血管床阻塞的肺循环的重组。
  • 批准号:
    62480136
  • 财政年份:
    1987
  • 资助金额:
    $ 5.12万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
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