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Mechanism of thalamo -cortical projection and intracerebral association

丘脑皮质投射与脑内关联的机制

基本信息

批准号：
02670370
负责人：
TSUJI Sadatoshi
金额：
$ 1.54万
依托单位：
Unversity of Occupational and Environmental Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

The mechanism of thalamo-cortical projection and intracerebral association system in the somatosensory pathways was studied in normal volunteers and cats. Cortical and subcortical somatosensory evoked potentials (SEPs) were recorded from the scalp, skull, dura mater, supra-and intra-cortex to evaluate the function of somatosensory pathways and primary sensory cortex (SI) in normal volunteers and cats. Topography of cortical SEPs over the scalp in normal controls during sleep stage revealed that cortical components (N20, P20, P22, P23 and N24) showed morphological changes and delayed peak latencies during sleep stage II and III/IV, and returned to the initial morphologies and peak latencies during REM sleep. These findings suggest that NREM sleep affects the origins of cortical SEPs which could be related to the synaptic function in the sensory cortex.Cortical and intracortical SEPs were recorded from the scalp, skull, dura mater, supra- and intra-cortex in cats. Morphologies and peak latencies of SEPs were essentially different between supra- and intra-cortical SEPs and scalp SEPs. Furthermore, cortical SEPs recorded from the medial, central and lateral SI areas with 3 to 5 mm intervals over the cortex were quite different morphologies and latencies in each electrode. These findings suggest that somatosensory pathways from the thalamus project not only to the SI areas but to frontal and parietal cortices.It is impossible to record cortical SEPs from both secondary sensory cortices (SII areas) in the cats.Neurotransmitters from the SI, motor and parietal cortices of the cats were analysed before, during and after the electrical stimulation of the radial nerve. The electrical stimulation of the radial nerve increased the acetylcholine release in the contralateral primary sensory area (SI) and motor area. Cholinergic transmission may be involved in the mechanism of cortical SEP generation.

本文用正常志愿者和猫研究了躯体感觉通路中丘脑-皮层投射和脑内联合系统的作用机制。本研究采用皮层和皮层下体感诱发电位（SEP）技术，对正常人和猫的头皮、颅骨、硬脑膜、皮层上和皮层内体感通路和初级感觉皮层（SI）的功能进行了研究。正常人睡眠期头皮皮层SEP的地形图显示，在睡眠II期和III/IV期，皮层成分（N20、P20、P22、P23和N24）出现形态学变化和延迟的峰潜伏期，在REM睡眠期恢复到初始形态和峰潜伏期。这些结果表明，NREM睡眠影响皮层SEP的起源，这可能与感觉皮层的突触功能有关。皮层和皮层内SEP记录在猫的头皮，头骨，硬脑膜，上和皮层内。皮层上、皮层内SEP与头皮SEP的形态和峰宽有本质的不同。此外，从皮质上方间隔3至5 mm的内侧、中央和外侧SI区记录的皮质SEPs在每个电极中的形态和潜伏期有很大不同。这些结果表明，丘脑的躯体感觉通路不仅投射到SI区，而且投射到额叶和顶叶皮质，不可能同时从猫的次级感觉皮质（SII区）记录皮层SEP。电刺激桡神经可增加对侧初级感觉区（SI）和运动区的乙酰胆碱释放。胆碱能传递可能参与皮层SEP的产生机制。