Mechanism of gravity-depend atelectasis : Analysis by nouradioactive xenon-euhance dynamic CT

重力依赖性肺不张的机制：无放射性氙增强动态CT分析

• 批准号: 02670495
• 负责人: IKEZOE Junpei
• 金额: $ 1.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670495/
• 关键词: gravity-depend Atelectasis; nonradioactive Xenon; dynamic Inhalation CT; ゼノンガス混合酸素; 呼吸不全

Reduction, in lung volume and shallow breathing produce progressive atelectasis in the dorsal lung(gravity-dependent atelectasis : GDA). We have developed an animal model of GDA(Invest Radiol 24 : 522, 1'989). The purpose of this study is to determine whether airway occlusion is a key factor for GDA.Methods : Dynamic inhalation CT was performed in ten rabbits, using 50%'iionradioactive xenon in oxygen on high frequency oscillatory ventilation(HFOV). Time-CT value curves were. -assumed to be described as exponential function, C=C_o(1-e^<-Kt>)(Kety's model). K value, which is equal to alveolar ventilation /alveolar volume, was calculated with re. gres. sion analysis. I. n experimental group(n=5)lung volume was reduced with artificial pneumoperitoneus of 10 cmH_2, while control group(n=5)did not have pneuxoperitoneum. Both groups were placed on HFOV for six hours and K values were calculated every one hour.Results : In all of the experimental group GDA was formed. In the dorial regions. wash-in of xenon. was observed and' K values increased just before GDA appeared'' Meanwhile K values in the ventral regions did not change significantly. The control group did not reveal-GDA'and K values did not change in either region.Conclusions : GDA is. related to the increase in alveolar ventilation /alveolar volume ratio. This result suggests that GDA is not caused. by airway occlusion. By means of this procedure-we can. diagnose GDA before"' the decrease in arterial oxygen pressure or. detection on CT images.

肺容量减少和浅呼吸会导致背肺进行性肺不张（重力依赖性肺不张：GDA）。我们已经开发了GDA的动物模型（Invest Radiol 24：522，1 '989）。方法：10只家兔在高频振荡通气（HFOV）条件下，用50%氙氧混合气体进行动态吸入CT检查。时间-CT值曲线。- 假定用指数函数描述，C=C_o（1-e^<-Kt>）（凯蒂模型）。计算肺泡通气量/肺泡容积的K值。格雷斯锡永分析I.实验组（n=5）采用10cmH_2人工气腹减少肺容积，对照组（n=5）不作人工气腹。结果：实验组均形成GDA。在多尔地区。氙的洗入。而腹侧区K值变化不明显。对照组未显示-GDA '和K值在两个区域均无变化。与肺泡通气/肺泡容积比的增加有关。这一结果表明GDA不是由其引起的。气道阻塞。通过这个程序，我们可以。在动脉血氧分压降低之前诊断GDA，或者。CT图像检测。

项目成果

池添 潤平: "Mechanism of gravityーdepend atelectasis:Analysis by nonradioactive xenonーenhanced dynamic CT" American review of respiratory disease.

Junpei Ikezoe：“重力依赖性肺不张的机制：非放射性氙气增强动态 CT 分析”美国呼吸系统疾病评论。

森本 静夫: "Dependent atelectasis:A study of regional ventilation by Xe enhanced dynamic CT" American review of respiratory disease.

Shizuo Morimoto：“依赖性肺不张：Xe 增强动态 CT 区域通气研究”美国呼吸系统疾病评论。