Apolipoprotein-Binding of Artificial Lipid Particles Assocated with Fat Infusion

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The intravascular metabolism of artificial lipid particles is quite similar to that of chylomicrons. Chylomicrons bind various kinds of apolipoprotein that regulate intravascular metabolism of chylomicrons, while artificial lipid particles do not contain any apolipoproteins. Apolipoprotein-binding mechanisms of artificial lipid particles were inverstigated. The research results are summarized as follows ;1. Artificial lipid particles acquire apolipoproteins C-II, C-III and E from high-density lipoprotein (HDL), immediately after their entry into bloodstream.2. Apolipoproteins C-II and C-III return to HDL after the hydrolysis of artificial lipid particles, while apolipoprotein E remains on the remnants of lipid particles.3. Artificial lipid particles bind apolipoproteins simply as the result of affinity of apolipoproteins for hydrophilic radicals on the surface of lipid particles.4. Depending on the rate of fat infusion, there is a limit to the capacity of HDL for donating apoC to artificial lipid particles. Fat particles that do not bind apoC may undergo the uptake by the reticulo-endothelial system, because this type of fat particle does not normally exist in humans. Accordingly, it is more appropriate not to infuse an emulsion of fat at a rate >0.1g TG/kg/h in a clinical setting.