Biological Research on Radio-Immunological Treatment of Sjogren's Syndrome

本文的研究成果主要有以下三点：1.利用图像分析中的膨胀算法，建立了一维形状分形维数的测量方法，并发表如下论文。干燥综合征患者的X线涎管造影用扩张法测量，发现其特征是腮腺导管系统的分形维数降低。简而言之，正常人唾液腺造影图的平均分形维数为1.64，干燥综合征的平均分形维数为1.39。分形维数降低表明干燥综合征患者腮腺导管数目减少或导管类型简化。目前，唾液腺造影片上出现点状影是诊断干燥综合征的标准。由于腮腺导管的变化先于疾病早期点状图像的出现，因此导管图案的分形维数预计将 关于我们 作为干燥综合征模型的小鼠品系NZB/WF 1的唾液腺造影和组织学研究表明，腮腺的导管模式变化和腺体中多倍体腺泡细胞数量的增加先于病灶形成，即，e.淋巴细胞浸润到腺体的纹状管区域。以病灶形成作为自身免疫性疾病的病理诊断标准。也就是说，实质的变化出现早于间质的变化，在疾病，所以前者预计是一个更好的诊断指标，导管分支系统的分形维数预计作为一个有用的指标，干燥综合征的诊断，所以它是需要了解什么调制其测量值在腮腺的实际导管模式。以分枝角度、分支率、树干长度、分枝数为参数，利用计算机绘图绘制二叉树型。通过改变参数，分析了树木图案的分形维数，并采用上述膨胀法进行了测量。分形维数被发现是依赖于一个非常复杂的方式和因素，以调节尺寸的参数是一个分支单位的大小，干像素的重量与分支点的单位，分支角度，分支比，分支单位之间的干扰，分支的数量，干扰和像素重量贡献的分支单位在不同的分支命令。这些因素的贡献还受到用于识别树型分形维数的尺度的影响。一个更普遍的结论是，一个实际形状的分形维数取决于所使用的测量尺度，而不是一个不变值。因此，在给出分维值时，必须提及所用度量的尺度。少

The research results are summarized into three points as follows.The method of fractal dimension measurements of 1-dimension shapes has been established by using dilation algorism of image analysis and published as listed below. X-ray sialograms of Sjogren's syndrome patients were measured by the dilation method and found to be characterized by lowered fractal dimensions of parotid gland ductal systems. Briefly, the averaged fractal dimension of sialograms of normal subjects was 1.64 and that of Sjogren's syndrome was 1.39. The lowered fractal dimension indicates the decreased number of parotid ducts or the simplification of the ductal patterns of Sjogren's syndrome patients. At present, the presence of punctuated images in their sialograms is adopted as the criteria for diagnosis of Sjogren's syndrome. Since the ductal changes of parotid glands precede the appearance of the punctuated images at an early phase of the disease, the fractal dimension of the ductal patterns is expected to … More serve as a better indicator for the progression of the disease.An investigation of sialograms and histology of the mouse strain, NZB/WF1 which serves as a model of Sjogren's syndrome and develops autoimmune disease with its age indicated that the ductal pattern changes of parotid glands and increased numbers of polyploid acinar cells in the glands precede the focus formation, i. e. infiltration of lymphocytes into the striated duct regions of the glands. The focus formation is adopted as a pathological criterion for the autoimmune disease. That is, the parenchyma changes appear earlier than mesenchyma changes in the disease and so the former is expected to be a better indicator for the diagnosis.Fractal dimesions of duct branching systems are expected as a useful indicator for the diagnosis of Sjogren's syndrome and so it is required to understand what modulates their measured values in practical ductal patterns of the parotid gland. The dichotomus tree patters were drawn by computer graphics using parameters of branching angle, branch ratio, length of stem, and number of branchings. The fractal dimensions of the tree patterns were analyzed by varying the parameters, of which measurements were carried out by using the dilation method as mentioned above. The fractal dimension was found to be depending on the parameter in a very complexed fashion and the factors to modulate the dimension are the size of a branch unit, weight of stem pixels compared with branch point of the unit, branch angle, branch ratio, interference between branch units, number of branchings, interference and pixel-weight contribution of branch units at different branch orders. These factors' contributions are furthermore influenced by scales of a measure used to recognize the fractal dimensions of the tree-patterns. A more general conclusion is that the fractal dimension of a practical shape depends on a scale of a measure used and so not an invariant value. Therefore, it is essential to mention the scale of a measure used when the fractal dimension value is presented. Less