Physiological rele of G-CSF in feto-placental unit

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Granulocyte colony-stimulating factor(G-CSF)is a glycoprotein growth factor required for the proliferation and differentiation of progenitors of neutrophils. G-CSF is synthesized not only by macrophages but also by placental tissues. Interestingly, specific binding of human G-CSF was observed on human placental membranes and trophoblastic calls. The human G-CSF receptors on human placental membranes were shown to consist of two molecular species of 150 kDa and 120kDa that could be specifically cross-linked to ^<125>I-labeled G-CSF. From human placental tissues, we purified two types of G-CSF receptors with Kd of 600 and 210 pM.Thus we have identified the receptors for human G-CSF on human placental membranes and traphoblastic cells, and the presence of the two types of receptors in these membranes suggest that human G-CSF plays some role in the feto-placental unit during human development.