DEVELOPMENT OF NEW CHIRAL CATALYSTS
新型手性催化剂的开发
基本信息
- 批准号:02640412
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The metal complex is very important in the homogeneous asymmetric catalytic reaction. Accordingly, new chiral metal complexes as catalyst was synthesized.Cobalt halogen complexes of composition CoX_2(L-L) containing different bidentate phosphine ligands (BINAP, DIOP, and CHIRAPHOS) have been prepared and characterized. The [CoX_2P] complexes were obtained from the reaction of CoCl_3゚6H_2O with 1 equiv. of bidentate phosphine ligands in CH_2Cl_2. ^<31>P NMR spectrum of this complex showed a singlet at -14.79 ppm. ^<31>P NMR chemical shift for the cobalt halogen complex depend on the ligated phosphine. The chemical shift is very close to the BINAP ligand. The structures of [CoCl_2(binap)] is determined by X ray crystallography : for [CoCl_2(binap)], C_<45>H_<34>P_2Cl_4Co, monoclinic, P2_1, a=10.870(4) A, b=13.024(4)A^^゚, C=14.316(3)A^^゚, beta=99.14(2)゚, V=2001(1)A^^゚^3, Z=2, R(F)=4.5%. This compound is very stable and melts without decomposition at 245-250 ゚C. Other related complexes have also been prepared and characterized.Nickel halogen complex of composition NiX_2(L-L) containing bidentate phosphine ligand (BINAP) have also been prepared.No using the initial catalyst for the asymmetric hydrogenation, perfluoroalkylation, and closs coupling reaction have been provided good results.
在均相不对称催化反应中,金属络合物是非常重要的。合成了新型手性金属配合物作为催化剂,合成了含不同双齿膦配体(BINAP、DIOP和CHIRAPHOS)的COX_2(L-L)卤化钴配合物,并对其进行了表征。CoCl3-゚-6H2O与1当量的CoCl3反应生成了[COX_2P]配合物。CH_2Cl_2中双齿膦配体的核磁共振谱为-14.79ppm。~lt;31>;P核磁共振钴卤化物的化学位移取决于连接的膦。化学位移与BINAP配体非常接近。[CoCl2(BINAP)][CoCl2(BINAP)]的结构经X射线单晶测定为:[CoCl2(BINAP)],C<;45>;H<;34>;P_2Cl4CO,单斜晶系,P2_1,a=10.870(4)A,b=13.024(4)A^゚,C=14.316(3)A^゚,β=99.14(2)゚,V=2001年(1)A^゚^3,Z=2,R(F)=4.5%。合成了含双齿膦配体的卤化镍配合物(NIX2(L-L))。在不使用初始催化剂的情况下,不对称氢化、全氟烷基化和克洛斯偶联反应均获得了良好的结果。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
H.TAKAYA,T.OHTA,S.INOUE,M.TOKUNAGA,M.KITAMURA,and R.NOYORI: "Asymmetric Hydrogenation of Allylic alcohols using BINAP-Ruthenium complexes:(S)-(-)-Citronellol(6-Octen-1-ol,3,7-dimethyl,(S)-)" Organic Synthesis.
H.TAKAYA、T.OHTA、S.INOUE、M.TOKUNAGA、M.KITAMURA 和 R.NOOYORI:“使用 BINAP-钌配合物对烯丙醇进行不对称氢化:(S)-(-)-香茅醇(6-辛烯)
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- 影响因子:0
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- 通讯作者:
H. Takaya, T. Ohta, S. Inoue, M. Tokunaga, M. Kitamura, and R. Noyori.: "Asymmetric Hydrogenation of Allylic alcohols using BINAP-Ruthenium Complexes : (S)-(-)-Citronellol (6-Octen-1-ol, 3,7-dimethyl, (S)-)" Organic Synthesis.
H. Takaya、T. Ohta、S. Inoue、M. Tokunaga、M. Kitamura 和 R. Noyori.:“使用 BINAP-钌配合物对烯丙醇进行不对称氢化:(S)-(-)-香茅醇 (6-
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- 影响因子:0
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Inoue,S.;Takaya,H.;Tani,K;Otsuka,S.;Sato.T,;Noyori,R.: "Mechanism of the Asymmetric lsomerization of Allylamines to Enamines Catalyzed by 2,2'ーBiS(diphenylphosphino)ー1,1'ーbinaphthylーRhodium Complexes" J.Am.Chem.Soc.12. 4897-4905 (1990)
Inoue,S.;Tani,K;Otsuka,T.;Noyori,R.:“2,2-BiS(二苯基膦)催化的烯胺不对称异构化” -1,1-联萘-铑配合物” J.Am.Chem.Soc.12. 4897-4905 (1990)
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INOUE Shin-ichi其他文献
Simulation of the relationship between muscle force and surface EMG during rapid contraction
快速收缩时肌肉力量与表面肌电关系的模拟
- DOI:
- 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
SAITOU Kenji;INOUE Shin-ichi - 通讯作者:
INOUE Shin-ichi
INOUE Shin-ichi的其他文献
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{{ truncateString('INOUE Shin-ichi', 18)}}的其他基金
Development of measuring instrument for muscle strength on hip joint which is concerned with elderly movement
与老年人运动相关的髋关节肌力测量仪的研制
- 批准号:
21500598 - 财政年份:2009
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
Anionic Homo- and Heteronuclear Bidentate Phosphine Ligands in Ruthenium Chemistry
钌化学中的阴离子同核和异核双齿膦配体
- 批准号:
433346-2012 - 财政年份:2012
- 资助金额:
$ 1.34万 - 项目类别:
University Undergraduate Student Research Awards
Electrosynthesis and Reactions of Platinum Triad Metal Cluster Containing Bidentate Phosphine
含双齿膦三元组铂金属簇的电合成及反应
- 批准号:
02640484 - 财政年份:1990
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)