japan and U.S, co-operative group study on the occurrence and growth of prostatic cancer

虽然潜伏性前列腺癌的患病率在日本和美国是相当相似的。后者前列腺癌的死亡率明显较高。采用几种方法对日本和美国前列腺癌的组织学特征和临床差异进行了评价：采用Gleason组织病理学分级系统进行组织病理学评价。世卫组织分级制度和区分不明确。增殖细胞核抗原（PCNA）和p53的免疫组化分析。核DNA浓度染色体分析的杂交化学。微量元素二维分布分析。等。我们发现，如果采用严格的A期亚分类标准，美国更多的A期前列腺癌可能被归为A2，这可能反映在临床前列腺癌发病率的显著差异上。日本临床前列腺癌的发现时间较晚，组织学分级较高，预后较差，且临床病程各有特点。

Although the prevalence of latent prostatic carcinoma is quite similar among Japanese and American. the mortality rates of prostatic carcinoma is significantly higher in the latter. Histologic characteristics and difference of clinical prostatic carcinoma in Japan and United States were evaluated in a several methods : histopathological evaluation using the Gleason's histologic grading system. WHO unclear grading system and differentiation. immnohistochemical and analysis of proliferating cell nuclear antigen(PCNA) and p53. hybridochemistry for chromosome analysis of nuclear DNA concentration. two dimensional distributional analysis of trace elements. etc. We found that much more stage A prostatic carcinoma in the United States might be fall into A2 if would be applied strict criteria for subclassification of stage A. and this may be reflected on the remarkable difference of incidence of clinical prostatic carcinoma. And much more clinical prostatic carcinoma from Japan seems to have delay on detection and higher histological grade with poorer prognosis, in addition, supposed to have different characteristics on clinical courses.