Research of Totally Implantable Linear Pulse Motor-Driven Artificial Heart

全植入式线性脉冲电机驱动人工心脏的研究

• 批准号: 03405005
• 负责人: YAMADA Hajime
• 金额: $ 14.34万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03405005/
• 关键词: Artificial heart; Mock testing; Electromagnetic actuator; Linear motor; Linear pulse motor; Animal testing; Permendur; Blood pump; 人工心臓システム,; リニアパルスモ-タ,; ジェリ-フィッシュ弁,; 動特性,; シュミレ-ション,; 制御アルゴリズム,; 模擬循環試験装置,; 寿命試験

Totally lmplantable Linear-type Artificial Heart under Animal TestingOur group has been considering the possibility of using a linear pulse motor (LPM) as a driving source, and has developed a series of artificial heart models with the motorThe newly developed implantable linear-type artificial heart (LAH) has two blood pumps, which are inflated and deflated by the LPM alternately, causing a pusher plates to pulsate the bloodThe LAH measures 85 mm in diameter * 95mm wide (0.55 litters total volume) , and weighs 1.2kg. The LPM comprises a flat mover as the secondary member and two stators as the primary member. Two linear bearings are used to support them. Both stators and mover are made of laminated thin layrs of Permendur with high saturation flux density.The LPM provides a kinetic thrust of 50-60 newtons at 60-100 beats per min., the speed required by an artificial heartA Windkessel-type mock circulatory system was used to evaluate the performance of the LAH.The results were good enough to meet the flow rate requirements of a human at rest. Maximum aortic pressure (AoP max) of 141 mmHg, maximum pulmonary arterial pressure (PAP max) of 28 mmHg, and maximum flow rate of 5.1 liters per min. were obtainedIn collaboration with Hiroshima University Medical School, animal testing using a sheep was conducted on September 24 1993. The experiment confimed that the implanted artificial heart could function as expected in a living body. The heart worked properly for up to two hoursThe development profect still faces a number of unsolved problems before device can be applied clinically, but it has been steadily advancing toward the final target

完全可植入直线型人工心脏的动物实验本课题组一直在考虑用直线脉冲电机（LPM）作为驱动源的可能性，并研制了一系列带有该电机的人工心脏模型。新研制的可植入直线型人工心脏（LAH）有两个血泵，由LPM交替充放气，导致推板使血液脉动LAH直径为85 mm，宽为95 mm（总体积为0.55升），重1.2 kg。LPM包括作为次级构件的扁平动子和作为初级构件的两个定子。两个线性轴承用于支撑它们。定子和动子都是由具有高饱和磁通密度的层压薄层Permendur制成。LPM在每分钟60-100次跳动时提供50-60牛顿的动力推力，采用Windkessel型模拟循环系统对LAH的性能进行了评价，结果表明，LAH能够满足人体静止时的流速要求。获得的最大主动脉压（AoP max）为141 mmHg，最大肺动脉压（PAP max）为28 mmHg，最大流速为5.1 L/min。1993年9月24日，与广岛大学医学院合作，使用绵羊进行了动物试验。实验证实，植入的人工心脏在活体中可以发挥预期的功能。心脏正常工作长达两个小时在设备能够应用于临床之前，开发项目仍然面临着许多未解决的问题，但它一直在朝着最终目标稳步前进

项目成果

H.Yamada: "Totally implantable linear-type artificial heart under animal testing" MEJ(Medical Equipment Journal of Japan). 37. 5,21 (1993)

H.Yamada：“动物试验中的完全植入式线性人工心脏”MEJ（日本医疗设备杂志）。

山口昌樹,山田一: "完全人工心臓駆動用リニアパルスモータの信頼性評価" 電気学会論文誌D. 114-D. 94-100 (1994)

Masaki Yamaguchi、Hajime Yamada：“驱动全人工心脏的线性脉冲电机的可靠性评估”日本电气工程师学会汇刊 D. 94-100 (1994)。

山田 一: "世界初のリニアモータ駆動型人工心臓の開発と人体模型“くにこ"" JTTASニューズ(日本工業技術振興協会). 5. 2 (1992)

Hajime Yamada：“开发出世界上第一个线性电机驱动的人工心脏和人体模型‘Kuniko’”JTTAS News（日本工业技术振兴协会）1992年5月2日。

山口 昌樹: "リニアモータ駆動型人心臓の特性試験" 日本応用磁気学会誌. 16. 461-466 (1992)

Masaki Yamaguchi：“直线电机驱动的人体心脏的特性测试”日本应用磁学学会杂志16. 461-466（1992）。

電気学会非線形磁気応用機器用語小委員会: "非線形磁気応用機器,電気学会電気専門用語集No.4" 電気学会, 30 (1991)

IEEJ 非线性磁性应用设备术语小组委员会：“非线性磁性应用设备，IEEJ 电气术语词汇表第 4 号”日本电气工程师学会，30（1991）