Selective segmental sclerotherapy of the liver cancer : Experimental and clinical study

肝癌的选择性节段硬化治疗：实验和临床研究

• 批准号: 03670550
• 负责人: MINAKUCHI Kazuo
• 金额: $ 1.22万
• 依托单位: OSAKA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670550/
• 关键词: Hepatic malignant tumor; Portography; Portal embolization; Absolute ethanol; Percutaneous transhepatic portography; 肝区域硬化術; 無水エタノール; interveutional radiology; 無水エタノ-ル; interventional vrdiology

Segmental ablation of the liver by transportal ethanol injection, Selective Segmental Screlotherapy (SSS), were developed as the treatment of the malignant hepatic tumor. Therapeutic efficacy and safety of SSS were investigated in rats. The hepatic segments injected with ethanol were observed as a yellowish-white area with distinct outline immediately after injection and showed complete necrosis within 2 to 3 weeks after injection. This findings indicate that necrosis of a targeted hepatic segment can be induced by SSS.The result of investigation with China ink suggest that SSS-associated tissue necrosis is attributable to the direct action of ethanol. Only slight increase in the concentration of ethanol in peripheral blood was observed, and no histological change was found in any other organs, and only slight effect on hepatic and renal function parameters was detected. It is concluded that SSS should be clinically applicable for the treatment of malignant hepatic tumor. Eight patients with hepatocellular carcinoma were performed treatment by SSS.The tumor decreased in size and clinical course was demonstrated by CT and angiographic findings.

通过运输乙醇注射进行肝脏节段性消融，即选择性节段性消融疗法（SSS），被开发为恶性肝肿瘤的治疗方法。在大鼠中研究了 SSS 的治疗效果和安全性。注射乙醇的肝段在注射后立即观察到轮廓清晰的黄白色区域，并在注射后2至3周内完全坏死。这一发现表明，SSS可诱导目标肝段坏死。墨汁研究结果表明，SSS相关的组织坏死可归因于乙醇的直接作用。仅观察到外周血乙醇浓度轻微升高，其他器官未发现组织学变化，仅检测到对肝肾功能参数的轻微影响。结论：SSS可用于临床治疗肝脏恶性肿瘤。 8 例肝细胞癌患者接受了 SSS 治疗。CT 和血管造影结果显示肿瘤体积缩小，临床病程明显缩小。

项目成果

K.Minakuchi et al.: "Intva-arterial digital subtraction patogaphy with a blood-isotonic,non iaric dimeric contrast medium" Radiation Medicine. 11. 43-48 (1993)

K.Minakuchi 等人：“使用血液等渗、非甘油二聚体造影剂进行的动脉数字减影病理学”放射医学。

K.Minakuchi et al: "Venograplry ander fluoraseopie mnitoring by digital subliastion opparaters" Radiation Medicine. 9. 95-97 (1991)

K.Minakuchi 等人：“Venograplry ander floraseopie m监控通过数字消减操作员”放射医学。

K.Minakuchi et al: "Hepatocellular carcinonee,associated with plyarterits nodosa with symptoms appeariy after intra-aitenal chemotherapy." Birt.J.Radiology. 64. 272-275 (1991)

K.Minakuchi 等人：“肝细胞癌，与结节性多动脉炎相关，并在子宫内化疗后出现症状。”

K.Minokuchi et al: "Hepatocelleilar covcinoma associated with polyarteritis nodrsa with symptans appearing after intra arteuial cbemotherapy" Brit.J.Radiology. 64. 272-275 (1991)

K.Minokuchi 等人：“肝细胞癌与结节性多动脉炎相关，并在动脉内化疗后出现症状”Brit.J.Radiology。

K.Nakamura et al: "Clinical evaluation of intermittent artevial infurin cbemothrapy with an implanted reservoir for hepato cellular carcinema." Cancer Chemother Phorndcol. 31. 93-98 (1992)

K.Nakamura 等人：“采用植入式储库的间歇性动脉阿弗林化疗疗法治疗肝细胞癌的临床评估。”