Effect of Peptide YY on Intestinal and Hepatic Blood Flow

本文研究了多肽YY （PYY）对狗内脏血、胆汁流动的影响。在全身麻醉下，狗接受100、400或800 pmol/kg/h剂量的猪PYY，持续1.5小时。在PYY输注前、输注中、输注后，采用氢气清除率法测定空肠、回肠、结肠浆膜下及肝脏的血流量。收集胆总管胆汁并测量其体积。100、400和800 pmol/kg/h的PYY显著抑制结肠血流量（p<0.05、p<0.05和p<0.01）。PYY剂量为800 pmol/kg/h时，空肠血流量显著降低（p<0.01）； PYY剂量为100 pmol/kg/h时，回肠血流量显著降低（p<0.05）。PYY不改变肝血流量，但以剂量依赖性方式抑制胆汁流量。这些数据表明，PYY对肠道血流具有抑制作用，但区域效应存在差异。PYY不影响肝血流；因此，它对胆汁流动的抑制作用可能不是肝灌注减少的结果。

The effect of peptide YY (PYY) on the flow of splanchnic blood and bile was investigated in dogs. Under general anesthesia, the dogs received porcine PYY at a dose of 100, 400, or 800 pmol/kg/h for 1.5 hours. Before, during, and after PYY infusion, blood flow was measured in the subserosa of the jejunum, ileum, and colon as well as in the liver using the hydrogen gas clearance method. Choledochal bile was collected and its volume measured. Colonic blood flow was significantly inhibited by 100, 400, and 800 pmol/kg/h of PYY (p<0.05, p<0.05, and p<0.01, respectively). Jejunal blood flow was significantly decreased by 800 pmol/kg/h of PYY (p<0.01), while ileal blood flow was decreased only by 100 pmol/kg/h of PYY and not by lager doses (p<0.05). PYY did not change hepatic blood flow, but inhibited bile flow in a dose-dependent manner. These data demonstrate that PYY has an inhibitory effect on intestinal blood flow with variations in regional effect. PYY does not affect hepatic blood flow; its inhibitory effect on bile flow is therefore probably not the result of decreased hepatic perfusion.