Effect of Peptide YY on Intestinal and Hepatic Blood Flow

肽YY对肠和肝血流的影响

• 批准号: 03670631
• 负责人: MIBU Ryuichi
• 金额: $ 1.34万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670631/
• 关键词: peptide YY; small intestine; colon; liver; blood flow; bile flow; hydrogen gas clearance method

The effect of peptide YY (PYY) on the flow of splanchnic blood and bile was investigated in dogs. Under general anesthesia, the dogs received porcine PYY at a dose of 100, 400, or 800 pmol/kg/h for 1.5 hours. Before, during, and after PYY infusion, blood flow was measured in the subserosa of the jejunum, ileum, and colon as well as in the liver using the hydrogen gas clearance method. Choledochal bile was collected and its volume measured. Colonic blood flow was significantly inhibited by 100, 400, and 800 pmol/kg/h of PYY (p<0.05, p<0.05, and p<0.01, respectively). Jejunal blood flow was significantly decreased by 800 pmol/kg/h of PYY (p<0.01), while ileal blood flow was decreased only by 100 pmol/kg/h of PYY and not by lager doses (p<0.05). PYY did not change hepatic blood flow, but inhibited bile flow in a dose-dependent manner. These data demonstrate that PYY has an inhibitory effect on intestinal blood flow with variations in regional effect. PYY does not affect hepatic blood flow; its inhibitory effect on bile flow is therefore probably not the result of decreased hepatic perfusion.

本文观察了肽YY（PYY）对狗内脏血流量和胆汁流量的影响。在全身麻醉下，犬接受100、400或800 pmol/kg/h剂量的猪PYY 1.5小时。在PYY输注之前、期间和之后，使用氢气清除法测量空肠、回肠和结肠的浆膜下以及肝脏中的血流量。收集胆总管胆汁并测量其体积。100、400和800 pmol/kg/h的PYY显著抑制结肠血流（分别为p<0.05、p<0.05和p<0.01）。800 pmol/kg/h的PYY显著降低空肠血流量（p<0.01），而回肠血流量仅由100 pmol/kg/h的PYY降低，而更大剂量的PYY不降低（p<0.05）。PYY不改变肝血流量，但以剂量依赖性方式抑制胆汁流量。这些数据表明，PYY对肠血流具有抑制作用，但区域效应不同。PYY不影响肝血流量;因此其对胆汁流量的抑制作用可能不是肝灌注减少的结果。

项目成果

M.Hotokezaka: "EFFECT OF PEPTIDE YY ON HEPATIC AND INTESTINAL BLOOD FLOW IN DOGS" GASTROENTEROLOGY.

M.Hotokezaka：“肽 YY 对狗肝和肠血流的影响”胃肠病学。

M.Hotokezaka: "INHIBITORY EFFECT OF PEPTIDE YY ON SPLANCHNIC BLOOD FLOW IN DOGS" European Journal of Gastroenterology & Hepatology. 9. S44 (1991)

M.Hotokezaka：“肽 YY 对狗内脏血流的抑制作用”欧洲胃肠病学杂志

M.Hotokezaka: "EFFECT OF PEPTIDE YY ON HEPATIC AND INTESTINAL BLOOD FLOW IN DOGS" Scandinavian Journal of Gastrocnterology.

M.Hotokezaka：“肽 YY 对狗肝和肠血流的影响”斯堪的纳维亚胃肠病学杂志。

M.Hotokezaka, S.Nakahara, T.Iwamoto, R.Mibu: "INHIBITORY EFFECT OF PEPTIDE YY ON SPLANCHNIC BLOOD FLOW IN DOGS" European Journal of Gas-troenterology & Hepato-logy. 3. S44 (1991)

M.Hotokezaka、S.Nakahara、T.Iwamoto、R.Mibu：“肽 YY 对狗内脏血流的抑制作用”欧洲胃肠病学杂志

M.Hotokezaka, S.Nakahara, T.Iwamoto, R.Mibu: "EFFECT OF PEPTIDE YY ON HEPATIC AND INTESTINAL BLOOD FLOW IN DOGS" Scandinavian Journal of Gastroenterology.

M.Hotokezaka、S.Nakahara、T.Iwamoto、R.Mibu：“肽 YY 对狗肝和肠血流的影响”斯堪的纳维亚胃肠病学杂志。