Experimental Studies of Influencing Agents to Neuromuscular Blocking Effects

影响神经肌肉阻滞作用的药物的实验研究

• 批准号: 03670736
• 负责人: SUZUKI Hajime
• 金额: $ 1.15万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670736/
• 关键词: Neuromuscular block; magnesium ion; muscle relaxants; Rocuronium; Calcium channel blockers; Diltiazem; Evoked electromyography; alpha-Bungarotoxin; パンクロニウム; Rocuronium; Vecuronium; 神経筋庶断; 複合筋活動電位面複曲線

[Aim of Investigation]The studies were aimed to evaluate electrophysiologically neuromuscular blocking mechanisms of some agents which are using to clinical anesthesia.[Methods]Compound action potentials (CAPs) which were derived from gastrocunemius muscles of cats by electrical stimulation of sciatic nerves were induced. Changes of amplitudes of CAPS, recovery curves (RCs) and tranin-of-four ratios (TOFRs) which were obtained from changing mode of stimulations were estimated for evaluation of their blocking effects.[Results]1. Neuromuscular blocks which were depended on serum [Mg^<2+>] were observed, and some evidences which were suggested that the blocks were caused from inhibition of transmitter release from motor nerves could be found.2. When the blocking effects by non-depolarizing relaxants were compared to that by Mg^<2+>, it was reconfirmed that the relaxants may have some inhibiting effects to motor nerve terminals.3. Rocuronium, a newly developed relaxant, produced non-depolarizing block, and its inhiditing effect to motor nerve terminals was similar as to be found in vecuronium.4. Diltiazem, a calcium channel blocker, showed a slight neuromuscular blocking effect, however, the effect was considered to be ignored ievel.

【研究目的】探讨临床麻醉中常用药物的神经肌肉电生理阻断机制。[方法]电刺激坐骨神经诱发猫腓肠肌的复合动作电位。通过估算不同刺激方式下cap、恢复曲线（RCs）和四次训练比值（TOFRs）的振幅变化，评价其阻断效应。观察到依赖于血清[Mg^<2+>]的神经肌肉阻滞，并发现一些证据表明该阻滞是由抑制运动神经的递质释放引起的。将非去极化松弛剂的阻断作用与Mg^<2+>的阻断作用进行比较，再次证实了非去极化松弛剂对运动神经末梢可能有一定的抑制作用。罗库溴铵是一种新开发的松弛剂，产生非去极化阻滞，其对运动神经末梢的抑制作用与维库溴铵相似。钙通道阻滞剂地尔硫卓显示出轻微的神经肌肉阻断作用，但该作用被认为是忽略的水平。

项目成果

Hidemori SHIRAISHI: "Study of neuromuscular transmission with evoked electromyography--11. Comparison between blocks by magnesium and by pancuronium (English Abstract)" MASUI 43 (4). (Accepted to publish). (1993)

Hidemori SHIRAISHI：“用诱发肌电图研究神经肌肉传递--11。镁阻滞剂和泮库溴铵阻滞剂的比较（英文摘要）”MASUI 43 (4)。

Hidemori Shiraishi, et al: "Fading Resporses in the Euoked FMG after Rocuronium in Cats" Canadian Jomnal of Anaesthesia. 39. 1099-1104 (1992)

Hidemori Shiraishi 等人：“猫罗库溴铵后 Euoked FMG 中的反应消失”加拿大麻醉杂志。