Does denervation supersensitivity develop after brain death ?
脑死亡后会出现去神经超敏反应吗?
基本信息
- 批准号:03670832
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Adult cats both sexs were used in this experiment In order to obtain experimental brain death, the bilateral internal carotid arteries were ligated and the vertebral arteries were clipped under Nembutal anesthesia. We emolyed this because of its reliability and simplicity after comparison of several procedures. Cats were always left on a respirator after discontinuation of blood circulation to the brain.The pupil became gradually dilated after the discontinuation of circulation to the brain. It moderately dilated and fixed around 2 hours later. Reflex pupillary dilatation to the sciatic nerve stimulation and the light reflex usually discernible during this transitional stage. Reflex pupillary dilatation is the ciliospinal reflex in a wide sense. It disappeared after the completion of brain death. This result strongly suggests that reflex pupillary dilatation could be an adjuvant diagnostic tool of brain death. Auditory brainstem response also disappeared in this experiment.Supersensitivity to the autonomic drugs, 0.125% pilocarpine in this experiment, was not proven at least 48 hours after brain death. Supersensitivity observed in human brain death does not appear to be caused by true denervation supersensitivity. It is known that the blood circulation in the brain discontinues or almost ceases under brain death. It is, therefore, reasonable to assume that supersensitivity observed in brain death is due to delay or stasis of the aqueous turnover, and accumulation or metabolic delay of the drugs in the iris and its surrounding tissues.
实验采用成年猫,雌雄猫均可,在Nembutal麻醉下结扎双侧颈内动脉,夹断椎动脉,获得实验性脑死亡。经过几种方法的比较,我们采用了这种方法,因为它的可靠性和简单性。在脑部血液循环停止后,猫总是戴上呼吸机。大脑血液循环停止后,瞳孔逐渐扩大。它在2小时后适度扩张并固定。瞳孔扩张对坐骨神经的刺激和光线反射在这一过渡阶段通常是可辨的。反射性瞳孔扩张是广义的纤毛反射。它在脑死亡后消失了。这一结果强烈提示反射性瞳孔扩张可作为脑死亡的辅助诊断工具。听觉脑干反应在实验中也消失了。对自主神经药物(本实验中为0.125%匹罗卡品)的超敏感性在脑死亡后至少48小时未被证实。在人类脑死亡中观察到的超敏似乎不是由真正的去神经超敏引起的。众所周知,在脑死亡的情况下,大脑中的血液循环停止或几乎停止。因此,我们有理由认为,脑死亡中观察到的超敏感是由于水质转换的延迟或停滞,以及药物在虹膜及其周围组织中的积累或代谢延迟所致。
项目成果
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OONO Shinji其他文献
OONO Shinji的其他文献
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{{ truncateString('OONO Shinji', 18)}}的其他基金
Study on double reciprocal innervation of the iris dilator muscle and sphincter muscle by a whole cell patch-clump technique
全细胞膜片簇技术研究虹膜扩张肌和括约肌的双向神经支配
- 批准号:
05454473 - 财政年份:1993
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)