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The study of the volume of blood capillary bed as revealed by analyzing the three dimensional microvascular architecture of blood vascular system in relation to the bone remodeling (1992)

通过分析血管系统的三维微血管结构揭示的毛细血管床体积与骨重塑的关系（1992）

基本信息

批准号：
03670858
负责人：
IWAKU Fumihiko
金额：
$ 0.13万
依托单位：
Asahi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

项目摘要

The purpose of this study is to clarify the three dimensional micro-vascular architecture of blood capillary bed on the bone surface in every process of bone remodeling mechanism and to discuss the possibility to able to calculate or not its volume in each phase during the bone remodeling.The capillary bed exists near the bone surface in every phase in the bone remodeling. The blood capillaries, tend to mainly to serpiginous runnings, form a single layer composed of irregular meshes varied in size. In the osteogenetic surface blood capillaries, run strongly serpiginous and curve strongly, form the irregular dense and sometimes fine meshes and so, the volume of the bed increases in quantity in an unit area set up on the bone surface for measurement. In the resorbing surface the blood capillaries, run weak serpiginous, make irregular fine meshes than in the resting surface and more rough meshes than in the osteogenetic one. The volume of this bed decreases in quantity in the unit area. In the resting surface the blood capillaries, tend to strongly serpiginous runnings and sometimes show curved running patterns, form mostly rough meshes, being larger in some places and circular in others, during the bone remodeling. The volume of this bed is smallest in quantity in the unit area.These facts are proved by discussing the results of the two dimensional measurements obtained with the histological serial sections. On the other hand, it is difficult to draw the three dimensional model in similar to the vascular architecture of the SEM observations and so, it seems that it is very complicated to provide a method for numerical calculation of the volume of capillary bed by analyzing the three dimensional model of the vascular architecture in the process of th bone remodeling.

本研究的目的是阐明骨重建机制各阶段骨表面毛细血管床的三维微血管构筑，并探讨骨重建各阶段毛细血管床体积的可计算性。毛细血管主要倾向于蜿蜒流动，形成由大小不一的不规则网孔组成的单层。在成骨表面毛细血管中，强烈地蜿蜒和强烈地弯曲，形成不规则的密集和有时精细的网格，因此，在用于测量的骨表面上设置的单位面积中，床的体积在数量上增加。在再吸收表面的毛细血管，运行弱蜿蜒，使不规则的细网格比在休息表面和更粗糙的网格比在成骨的一个。在单位面积内，该床的体积减少。在骨重建期间，在静止表面中，毛细血管倾向于强烈的蜿蜒流动，有时显示弯曲的流动模式，形成大多数粗糙的网格，在某些地方较大，在其他地方呈圆形。在单位面积上，该床的体积最小，这一点通过对组织学连续切片二维测量结果的讨论得到了证实。另一方面，由于难以绘制出与扫描电镜观察到的血管结构相似的三维模型，因此，通过分析骨重建过程中血管结构的三维模型来提供一种数值计算毛细血管床体积的方法显得非常复杂。