Integrative studies on acclimatization mechanism to extreme altitude hypoxia in Himalayan areas - A joint project of Kyoto and Chida University

对巴基斯坦罕萨县的老年功能评估和社会文化调查进行了调查。罕杂地区75岁以上老年人的神经行为功能得分高于日本老年人。虽然日本的女性老年人比男性老年人更健康，但在日本，男性老年人比女性老年人更健康。视觉模拟评定量表测评的男性老年人主观幸福感得分显著低于男性老年人(P<0.05)。在罕萨地区不同的村庄，年龄与收缩压的相关性是不同的。此外，在众所周知的长寿地区Equado的VilCabamba以及罕萨，也进行了老年功能评估和社会文化调查。在维尔卡班巴、罕萨和日本，神经行为功能各指标的得分与年龄呈显著正相关，说明我们所采用的各项指标均适用于老年功能的评估方法。维尔卡班巴高龄老人的神经行为功能得分不高于日本。在主观健康、经济状况和幸福感方面，维尔卡班巴老年人得分低于日本老年人。此外，还调查了安第斯地区儿童心血管疾病的老年功能评估、发育里程碑和危险因素。提示生物衰老和发育既受遗传因素的影响，也受社会文化生活方式的影响。

Geriatric functional assessment and socio-cultural survey in Hunza in Pakistan were investigated. The scores in neurobehavioral functions in the older elderly (over 75 year-old)in Hunza were higher than the older elderly in Japan. Al though the female elderly were healthier than the male one in Japan, the male elderly were healthier than the female one in Hunza. The scores in subjective happiness evaluated by visual analogue scale was significantly lower in the female elderly in Hunza than in the male elderly in Hunza or Japan elderly population. The correlation between age and systolic blood pressure was different among the villages in Hunza area.Geriatric functional assessment and socio-cultural survey was investigated also in Vilcabamba in Equador which was known to be the area of long-living people, as well as Hunza. The scores in each index of neurobehavioral functions were significantly correlated with age in Vilcabamba as well as in Hunza and in Japan, indicating that each indices we adopted was suitable to the method to assess the geriatric functions. The scores in neurobehavioral functions in the older elderly in Vilcabamba were not higher than those in Japan. The scores in subjective healthiness, economical condition and happiness were lower in the elderly in Vilcabamba than in ones in Japan.As well as geriatric functional assessment, development milestone and risk factors for cardiovascular diseases in children in Andean area were also investigated.Both biological aging and development were suggested to be influenced by not only genetic factors but also socio-cultural life style.