Development of Direct Synthesis of Optically Active Compounds
光学活性化合物直接合成研究进展
基本信息
- 批准号:03555178
- 负责人:
- 金额:$ 10.94万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Developmental Scientific Research (B)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Several BINAP derivatives have been prepared and their donor-acceptor propeties have been elucidated. New cationic complexes [RuX(binap)(arene)]Y were synthesized in high yields and their catalytic abilities as well as their behaviors in solution have been investigated. Optimization of the reaction conditions of asymmetric hydrogenation of methyl 2-benzamidomethy1-3-oxobutanoate by use of these complexes as catalysts afforded the corresponding alcohol in 98% de and 99% ee. Asymmetric hydrogenation of alpha-alkylidenecyclopentanones, alkylidenelactones, alkenyl ethers, and alpha-keto esters has also been performed in high enantioselectivities. Hydrogenation of various 1,2-benzocycloalkanones and 3-thiacycloalkanones catalyzed by newly developed BINAP-ir(I)-aminophosphine systems afforded the corresponding secondary alcohols in up to 96% ee.
合成了几种BINAP衍生物,并阐明了它们的供体-受体性质。高产率合成了新的阳离子配合物[Rux(BINAP)(芳烃)]Y,考察了它们的催化性能及其在溶液中的行为。优化了2-苯甲酰胺甲基-3-氧代丁酸甲酯的不对称加氢反应条件,在98%De和99%ee中得到了相应的醇。α-亚烷基环戊酮、亚烷基内酯、烯基醚和α-酮酯的不对称氢化反应也具有很高的对映体选择性。新开发的BINAP-Ir(I)-氨基膦体系催化各种1,2-苯并环烷酮和3-硫代环烷酮的加氢反应,生成相应的仲醇,最高可达96%ee。
项目成果
期刊论文数量(26)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K.MASHIMA,Y.MATSUMURA,K.KUSANO,H.KUMOBAYASHI,N.SAYO,Y.HORI,T.ISHI,S.AKUTAGAWA,H.TAKAYA: "Highly Stereoselective Asymmetric Hydrogenation of 2-Benzamidomethyl-3-oxobutanoate Catalyzed by Cationic binap-Ruthenium II Complexes" J.Chem.Soc.,Chem.Commun.609-61
K.MASHIMA,Y.MATSUMURA,K.Kusano,H.KUMOBAYASHI,N.SAYO,Y.HORI,T.ISHI,S.AKUTAGAWA,H.TAKAYA:“2-苯甲酰氨基甲基-3-氧代丁酸酯的高度立体选择性不对称氢化反应
- DOI:
- 发表时间:
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- 影响因子:0
- 作者:
- 通讯作者:
T.OHTA,T.MIYAKE,M.SEIDO,H.KUMOBAYA,S.AKUTAGAWA,H.TAKAYA: "Asymmetric Hydrogenation of Unsaturated Carbonyl Compounds Catalyzed by BINAP-Ru(II)Complexes" Tetrahedron Lett.33. 635-638 (1992)
T.OHTA、T.MIYAKE、M.SEIDO、H.KUMOBAYA、S.AKUTAGAWA、H.TAKAYA:“BINAP-Ru(II) 配合物催化的不饱和羰基化合物的不对称氢化”四面体 Lett.33。
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- 影响因子:0
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H.TAKAYA,T.OHTA,K.MASHIMA: "New 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II)Complexes for Asymmetric Hydrogenation" American Chemical Society,Washington DC, 20 (1992)
H.TAKAYA,T.OHTA,K.MASHIMA:“用于不对称氢化的新型 2,2-双(二苯基膦)-1,1-联萘基-Ru(II)配合物”美国化学会,华盛顿特区,20(1992 年)
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- 影响因子:0
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K.Mashima, Y.Matsumura, K.Kusano, H.Kumobayashi, N.Sayo, Y.Hori, T.Ishizaki, S.Akutagawa, and H.Takaya: "Highly Stereoselective Asymmetric Hydrogenation of 2-Benzamidomethyl-3-oxobutanoate catalysed by Cationic binap-Ruthenium^<II> Complexes." J.Chen.Soc.
K.Mashima、Y.Matsumura、K.Kusano、H.Kumobayashi、N.Sayo、Y.Hori、T.Ishizaki、S.Akutakawa 和 H.Takaya:“2-苯甲酰氨基甲基-3-氧代丁酸酯的高度立体选择性不对称氢化
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H.Takaya: "Super Chiral Ligands (in Japanese)." Kagaku. 46. 171-174 (1991)
H.Takaya:“超级手性配体(日语)”。
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TAKAYA Hidemasa其他文献
TAKAYA Hidemasa的其他文献
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{{ truncateString('TAKAYA Hidemasa', 18)}}的其他基金
Chemical Behaviors and Synthetic Applications of Hypovalent Organic Metastable Species Under WellーControlled Conditions
良好控制条件下低价有机亚稳物质的化学行为及合成应用
- 批准号:
01300011 - 财政年份:1989
- 资助金额:
$ 10.94万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Development of New Chiral Transition-Metal Catalysts for Highly Efficient Asymmetric Synthesis
开发用于高效不对称合成的新型手性过渡金属催化剂
- 批准号:
01470095 - 财政年份:1989
- 资助金额:
$ 10.94万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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