Fyn-STEP-Tau axis: the nanoscale mechanisms of synaptic plasticity

Fyn-STEP-Tau 轴：突触可塑性的纳米级机制

• 批准号: DP240102217
• 负责人: Dr Pranesh Padmanabhan
• 金额: $ 45.46万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102217
• 关键词: Fyn; STEP; Tau; axis; nanoscale

This project investigates how brain cells use their molecular machinery to communicate with one another. At the heart of this process lies the synapses, the contact points that connect brain cells. This project will employ an innovative combination of quantitative microscopy techniques, gene knockout mouse models, and advanced computational and mathematical analyses to generate new knowledge on how a crucial set of proteins organises in space and time to regulate synaptic connectivity. This will provide significant benefits, including molecular-level insight into the inner workings of the brain and interdisciplinary training for students. The expected outcomes include a deeper understanding of brain functions, such as learning and memory.

这个项目研究脑细胞如何使用它们的分子机制相互交流。在这个过程的核心是突触，连接脑细胞的接触点。该项目将采用定量显微镜技术，基因敲除小鼠模型以及先进的计算和数学分析的创新组合，以产生关于一组关键蛋白质如何在空间和时间中组织以调节突触连接的新知识。这将带来巨大的好处，包括对大脑内部工作的分子水平的洞察力和对学生的跨学科培训。预期的结果包括对大脑功能的更深入了解，如学习和记忆。