Development of The Jet Pump for Left and Right Heart Assist.
Development of The Jet Pump for Left and Right Heart Assist.
批准号:
05557063
负责人:
UCHIDA Naoki
金额:
$7.62万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1995
中文摘要
我们开发了微型喷射泵作为心脏辅助装置。喷射泵由喷嘴、入口、喉部和扩散器组成。所有部件均装配在同一轴上的锥管或柱管上,泵内无活动部件。为了得到两种环境下的数据,我们制作了两种模型。一个由黄铜制成的是用于台架试验的类型,以检查泵的特性,另一个由丙烯酸树脂和乙烯基氯化物制成的是动物实验的类型。在台架试验中,我们使用40%甘油溶液,在40 mmHg后负荷下,以1010 ml/min的喷射流量获得3070 ml/min的泵输出。我们用光纤激光测速仪测量了血流速度,最大射流速度在10 m/s以内,这是之前报道的机械溶血的相对安全区域。我们使用成年山羊进行动物实验。当自然心脏在左心搭桥辅助下处于心室纤颤状态时,右心系统射流1.8或2.0 l/min可使左心输出量增加2.5 l/min。综上所述,尽管喷射泵在临床应用中还存在溶血、定位、泵效等诸多问题,但我们希望它能成为一种实用的右心辅助装置。微喷泵在左心辅助和儿童心脏辅助中的应用有待进一步研究。
英文摘要
We have developed the micro jet pump as a heart assist device. Jet pump was consisted in order NOZZLE,INLET,THROAT and DIFFUSER.All compornents were fabricated to cone or column pipe on the same axis and there was no moving parts in this pump. We made 2 types of models in order to get the datum in 2 enviroment. One made from brass was the type for bench test to examine the caracteristics of the pump, and another made from acril resin and vinylchrolide was the type for animal experiment.In the bench test, we got 3070 ml/min of pump output by 1010 ml/min of jet flow volume against 40 mmHg afterload using 40% glycerine solusion. We measured flow velosity by Fiberoptic Laser Velocimeter, and maximum jet flow velosity was within 10 m/sec which was reported previously as the comparativery safe zone for machanical hemokysis.We performed animal experiments using adult goat. When natural heart was the condition of ventricular fiblilation under the assist of left heart bypass, 1.8 or 2.0 l/min of jet flow in right heart system made 2.5 l/min of increase of left heart output.In conclusion, although there remain many probrems for clinical usage of jet pump, including heamolysis, positioning and pump efficiency, we hope it would be useful device for right heart assist. And the use of micro jet pump for left heart assist and child heart assist should be study in the future.
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依托单位:
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