Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.

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Our studies on predition and control of drug disposition in body for promoting the effectiveness and safety by means of pharmacokinetics based on physiological and biochemical mechanism are summarized as follows. M.Hayashi evaluated and promoted intestinal absorption of drugs by using rat intestinal duct and Caco-2 cell. M.Hashida presented a new technology in order to clarify mechanism of drug absorption and to promote it. A.Tsuji clarified mechanism of drug transport through cell membrane and developed the regulation successfully. K.Inui analyzed precisely mechanism of tubular secretion of drug by using cultured urinal epidermal cell. S.Awazu clarified molecular mechanism of appearance of drug toxic action. J.Watanabe and N.Yata succeeded prediction of tissue distribution in macro molecular compounds and in basic drugs, respectively. T.Terasaki analyzed and clarified transport into tissue of virus based on the receptor distribution in tissues and cell killing kinetics of anticancer drugs including DNA topoisomerase I and II.T.Iga succeeded prediction neurotoxic convolution by histamine H_2 receptor antagonists. S.Higuchi developed individualized dosing by using population kinetics model. Y.Sugiyama succeeded regulation of a receptor mediated clearance of biologically active macromolecule. M.Hanano generalized the whole studies and analyzed relationship between pharmacokinetics and action for analgesics in order to develop pharmacokinetics based on physiological and biochemical mechanism invoived by drug effective and its toxicity. These significant results were presented to open seminar held on September 26th in 1994 at Yasuda hall in the university of Tokyo, Hongo Tokyo Japan.