Biomedical studies on the age-related changes of the sound trasduction mechanisms and its clinical applidations.

该项目的首席研究员Takasaka博士和他的团队研究了与年龄相关的声音传导系统变化的生物学机制以及老年性耳聋的耳科学证据。这个项目是通过为听力受损的老年人开发完全数字化的便携式助听器（CLAIDHA）来完成的。自1995年该项目启动以来的前两年，我们主要进行了周边声音转导机制的基础生物学研究，并在美国佛罗里达州的美国耳科研究协会（Association For Research in ot喉）的mid - winter会议及国内其他耳科相关会议上进行了报告。1995年7月，终于完成了CLAIDHA的生产，并获得了卫生和福利部的临床应用许可。因此，我们开始了对老年性耳聋的鉴别诊断以及新开发的CLAIHDA的装配程序的听力学临床研究。在美国马里兰州贝塞斯达举行的助听器新趋势国际会议上报道了CLAIDHA临床应用的初步研究。如上所述，我们能够为加速老年性耳聋的研究做出贡献，并为老年听障人士提供一种新开发的辅助系统。我们要感谢教育部在1993年至1995年期间提供的科研补助金(A)。

Dr. Takasaka, head investigator of this research project, and his group has studied biological mechanisms of age-related changes of the sound transduction systems as well as otologic evidences of the presbycusis. This project has been accomplished by the development of the completely digitalized portable hearing aid (CLAIDHA) for elders who suffer from hearing impairment.For the first two years since this project has started in 1995, we have mainly spent a time performing the basic biology of the peripheral sound transduction mechanisms, and the results obtained have been reported at the Midwinter Meeting of the Association for Research in otlaryngology in Florida and other otology related domestic meetings.In July 1995, production of the CLAIDHA has finally been completed and permission for clinical application was obtained from the Ministry of Health and Welfare. Therefor, we have started audiometric clinical studies on the differential diagnosis for the presbycusis as well as on the fitting procedures for the newly developed CLAIHDA.The preliminary studies of the clinical applications for the CLAIDHA was reported at the International Conference on the New Trend of the Hearing Aid held at Bethesda, MD,USA.As mentioned above, we have been able to contribute to the acceleration for the research in presbycusis and also to provide a newly developed aiding system for the aged peoples with hearing impairment. We would like to express our thanks to the Ministry of Eduction for providing Grant-in Aid for Scientific Reaserch (A) from 1993 to 1995.