How novel ribosomal RNA gene repeat variants drive cellular function

新型核糖体 RNA 基因重复变异如何驱动细胞功能

• 批准号: DP220101352
• 负责人: Prof Eduardo Eyras
• 金额: $ 45.85万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101352
• 关键词: How; novel; ribosomal; RNA; gene

The hundreds of ribosomal RNA gene repeat copies are a remarkable part of our genomes, as they encode the machinery responsible for all cellular protein synthesis and shape the structure of the nucleus. However, due to their high degree of sequence similarity, they still have not been assembled into the human genome reference. This project will resolve this impasse and furthermore uncover the functional impacts of a newly identified molecular diversity in the ribosomal RNA gene repeats. Outcomes include new paradigms for how the ribosomal RNA gene repeats drive protein synthesis and genome structure, and a blueprint to develop novel genomics applications for human health, biotechnology, and agriculture.

数百个核糖体RNA基因重复拷贝是我们基因组中值得注意的一部分，因为它们编码了负责所有细胞蛋白质合成和塑造细胞核结构的机制。然而，由于它们高度的序列相似性，它们仍然没有被组装成人类基因组参考。该项目将打破这一僵局，并进一步揭示新发现的核糖体RNA基因重复序列中分子多样性的功能影响。成果包括核糖体RNA基因重复如何驱动蛋白质合成和基因组结构的新范例，以及为人类健康、生物技术和农业开发新的基因组学应用的蓝图。