Endocrinological and thermal effects on alpha_1-adrenergic-receptor-mediated contraction of the prostate.

对α_1-肾上腺素受体介导的前列腺收缩的内分泌和热效应。

• 批准号: 06404057
• 负责人: KAWABE Kazuki
• 金额: $ 11.65万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06404057/
• 关键词: Benign prostatic hyperplasia; laser; androgen; alpha_1-adrenergic receptor

The contraction of the prostate induced by alpha_1-adrenergic receptor agonist was examined in regards to the possible changes in properties when exposed to endocrinological and thermal stimuli. Thermal effects by laser irradiation induced little changes in contraction force and Kd and Bmax of alpha_1-adrenergic receptor of the human prostate. Castrated rat prostate was used as the model to examine the possible changes of the receptor by androgen deprivation. The contraction force per a unit weight of the prostate was two to three-fold increased by castration, whilst the binding assay between prazosin and receptor and inhibition assay competed by prazosin or phenylephrine showed no essential changes in receptor properties. These results indicate that alpha_1-adrenergic receptor is little affected by endocrionological and thermal interventions. The clinical implications of these characters of alpha_1-adrenergic receptor of the prostate warrant further studies.

检查由α_1-肾上腺素能受体激动剂诱导的前列腺收缩，以了解当暴露于内分泌和热刺激时性质可能发生的变化。激光照射的热效应引起人前列腺的收缩力以及α_1-肾上腺素能受体的Kd和Bmax的微小变化。以去势大鼠前列腺为模型，检测雄激素剥夺可能引起的受体变化。去势后前列腺每单位重量的收缩力增加了两到三倍，而哌唑嗪与受体之间的结合测定以及哌唑嗪或去氧肾上腺素竞争的抑制测定显示受体性质没有本质变化。这些结果表明α_1-肾上腺素能受体受内分泌和热干预的影响很小。前列腺α_1-肾上腺素能受体的这些特征的临床意义值得进一步研究。

项目成果

Homma,Yukio: "Response criteria for the therapeutic efficacy of treatment of benign prostatic hyperplasia." Int.Urol.2. 33-38 (1995)

Homma，Yukio：“良性前列腺增生治疗效果的反应标准。”

Moriyama,Nobuo: "Evaluation of α_1-adrenoceptor subtypes in human hypertrophied prostate using[^2H|YM617.an α_1-selective antagonist." Acta Histochem.et Cytochem.27. 219-225 (1994)

Moriyama, Nobuo：“使用 [^2H|YM617.an α_1-选择性拮抗剂评估人类肥大的前列腺中的 α_1-肾上腺素受体亚型。” Acta Histochem.et Cytochem.219-225 (1994)。

Moriyama,Nobuo: "Age-related changes in alpha_1-adrenoceptors in rat prostate." Urol.Res.(in press).

Moriyama,Nobuo：“大鼠前列腺中 α_1-肾上腺素受体的年龄相关变化。”

Kawabe,Kazuki: "Rationale for the use of α-blockers in the teatment of benign prostatic hyperplasia" Int.J.Urol. 1. 203-211 (1994)

Kawabe, Kazuki：“使用 α-阻滞剂治疗良性前列腺增生的基本原理”Int.J.Urol。1. 203-211 (1994)

Kawabe,K.: "Rationale for the use of α-blockers in the treatment of benign prostatic hyperplasia (BPH)." Int.J.Burol.1. 203-211 (1994)

Kawabe, K.：“使用 α 受体阻滞剂治疗良性前列腺增生 (BPH) 的基本原理。Int.J.Burol.1 (1994)。”