Endocrinological and thermal effects on alpha_1-adrenergic-receptor-mediated contraction of the prostate.

本文研究了α_1-肾上腺素能受体激动剂引起的前列腺收缩，以及在内分泌和热刺激下可能发生的特性变化。激光热效应对人前列腺α_1-肾上腺素能受体的收缩力、Kd和Bmax无明显影响。以去势大鼠前列腺为模型，观察雄激素剥夺对受体的影响。去势使单位重量的前列腺收缩力增加两到三倍，而哌唑嗪与受体的结合试验和由哌唑嗪或苯肾上腺素竞争的抑制试验表明，受体的性质没有本质的变化。这些结果表明α_1-肾上腺素能受体几乎不受内分泌和热干预的影响。前列腺α_1-肾上腺素能受体这些特征的临床意义值得进一步研究。

The contraction of the prostate induced by alpha_1-adrenergic receptor agonist was examined in regards to the possible changes in properties when exposed to endocrinological and thermal stimuli. Thermal effects by laser irradiation induced little changes in contraction force and Kd and Bmax of alpha_1-adrenergic receptor of the human prostate. Castrated rat prostate was used as the model to examine the possible changes of the receptor by androgen deprivation. The contraction force per a unit weight of the prostate was two to three-fold increased by castration, whilst the binding assay between prazosin and receptor and inhibition assay competed by prazosin or phenylephrine showed no essential changes in receptor properties. These results indicate that alpha_1-adrenergic receptor is little affected by endocrionological and thermal interventions. The clinical implications of these characters of alpha_1-adrenergic receptor of the prostate warrant further studies.