Improvement of Long Term Survival for Malignant Ovarian Tumor

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PVB regimen was superior to CAP regimen for ovarian cancer (p<0.05). Although difference of survival rate increased between 2 regimems within 24 months, thereafter survival rates decreased gradually at the same rate. Furthermore, there were no difference observed between 2 regimen in disease free survival. These results suggested that primary treatment including operation and chemotherapy was very important to improve survival for ovarian cancer. One hundred and fifty borderline malignancy cases were also analyzed. One hundred and twenty-five cases were stage I and 52 cases were managed conservely pregnancy potencial. Although stage I cases received no adjuvant therapy after operation, no cases died, suggesting that adjuvant therapy was meanless in stage I cases. On the other hand, 9 cases died among 25 with stage II or more. Thus, adjuvant chemotherapy including cisplatin might be performed in advanced cases. However, adjuvant chemotherapy would not be effective on mucinous borderline cases as well as mucinous cancer. MMPs and TIMPs have been focused for cancer cell invasion and metastasis. These proteins were examined in gynecologic cancer tissues by using gelatin zymography and reverse zymography. The secretion of MMPs increased more in cancer tissues than that in normal tissues and specially MMP-9 increased remarkably in cancer tissues, although this enzyme was secreted little in normal tissues. The secretion fo TIMP-1 increased more in cancer tissues than that in normal tissues. Furthermore, we examined these proteins in peritoneum, myometrium and ovary. MMP-9 was secreted mostly in peritoneum and TIMP-1 in ovary. Conditioned medium of these normal tissues had the potency to induce MMPs and TIMPs from ovarian cancer cells. These results suggested that the influence of normal tissues on cancer cells was strongly associated with cancer cells invasion.