STUDY ON THE REALIZATION OF A COMPACT PROTON ACCELERATOR FOR CANCER THERAPY

实现用于癌症治疗的紧凑型质子加速器的研究

• 批准号: 06559011
• 负责人: NODA Akira
• 金额: $ 11.2万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06559011/
• 关键词: Proton Cancer Therapy; Combined-function Synchrotron; Resonant Beam Extraction; Synchronization with Breezing; Compact Gantry; Untuned RF Acceleration Cavity; Multi-feed Coupling; Digital Synthesizer; 陽子シンクロトロン; ラティス設計; シンクロトロン加速; 周波数制御; 非同調型高

Radiation cancer therapy is noteworthy from the point of view of quality of life of the patients because of the merit of keeping the function of the body. Especially proton therapy has become important because it is equivalent to the X ray in the biological effect and tremendous amount of experience of treatment with X ray can be effectively utilized in addition to the fact that it can localize the radiation dose to the affected part. In the present study, we have developed a compact proton accelerator for cancer therapy in order to enable wide spread use of proton therapy.In detail, the following studies have been advanced priented for proton synchrotron which can be easily operated with various energies.1.Combined-function lattice is adopted for the merit of compactness and eazy operation. As the slow beam extraction method, we have adopted the new scheme to apply a transverse RF electric field keeping the betatron tune to be constant, which is suitable for the synchronization of the … More beam irradiation with breathing of the patient.2.After the reduction of the required acceleration voltage by optimization of the acceleration pattern, we have adopted an untuned RF accelerating cavity, which avoided the complicated tuning of the RF cavity. By invention of a new power feeding method called multi-feed coupling, efficiency of utilization of the applied RF power has been largely improved by the reduction of reflection power. An RF acceleration cavity applicable to a real proton synchrotron dedicated for cancer therapy has been completed with the untuned type excited by a 2kW solid state amplifier. By the high power test, it is found to be well put to practical use from the points of view of generated gap-voltage, necessary input power and its temperature rise.3.An RF control device fabricated on the boards of the personal computer has been developed adopting a digital synthesizer with good purity of frequency. With use of this devive, feed back control with beam position and phase error is considered to become unnecessary if the step frequency control according to the change of the magnetic field is precise enough. Thus the daily routine operation of the synchrotron is expected to be possible. Less

从患者生活质量的角度来看，放射治疗是值得关注的，因为它具有保持身体功能的优点。尤其是质子治疗，因为它在生物效应上与X射线相当，并且可以有效地利用大量的X射线治疗经验，此外它还可以将辐射剂量定位到受影响的部位。在本研究中，我们开发了一台紧凑型质子加速器用于癌症治疗，以实现质子治疗的广泛应用。具体来说，我们对质子同步加速器进行了以下研究：1.结合功能格子的优点，紧凑和容易操作的优点。在慢束提取方面，我们采用了一种新的方案，即施加一个横向的射频电场来保持电子束管的调谐恒定，这非常适合于…的同步通过对加速模式的优化降低了所需的加速电压后，采用了未调谐的射频加速腔，避免了对射频腔的复杂调谐。通过发明一种称为多馈耦合的新的馈电方法，通过减少反射功率，大大提高了所施加的射频功率的利用效率。用2kW固体放大器激励的非调谐型高频加速腔已建成，适用于癌症治疗专用质子同步加速器。通过高功率测试，从产生的间隙电压、必要的输入功率及其温升的角度来看，其具有很好的实用价值。3.采用具有良好频率纯度的数字频率合成器，研制了一种基于PC机板卡的射频控制装置。利用这种装置，如果根据磁场的变化进行步进频率控制的精度足够高，则认为不需要考虑束流位置和相位误差的反馈控制。因此，同步加速器的日常运行有望成为可能。较少

项目成果

Kazuo Hiramoto et al.,: "A Compact Proton Synchrotron with a Combined Function Lattice for Medical Use" Proceedings of NIRS International Seminar on the Application of Heavy Ion Accelerator to Radiation Therapy of Cancer in connection with XXI PTCOG Meeti

Kazuo Hiramoto 等人，“医疗用组合功能晶格的紧凑型质子同步加速器”NIRS 国际研讨会论文集，该研讨会关于重离子加速器在癌症放射治疗中的应用，与 XXI PTCOG Meeti 相关

J.Hirota,K.Hiramoto,M.Katane.Y.Iwashita,A.Noda and M.Inoue: "A Ferrite-Loaded Untunned Cavity with Multiple Power Feeding" Bulletin of the Institure for Chemical Research,Kyoto University. 73(in print). (1995)

J.Hirota、K.Hiramoto、M.Katane.Y.Iwashita、A.Noda 和 M.Inoue：“具有多重供电的铁氧体负载未调谐腔”京都大学化学研究所通报。

Kooji Matsuda et al.,: "A Resonant Beam Extraction Scheme for a Compact Synchrotron" Beam Science and Technology, Activity Report, Nuclear Science Research Facility, Institute for Chemical Research, Kyoto Univ.1. 17-20 (1996)

Kooji Matsuda 等人，“紧凑型同步加速器的共振束提取方案”光束科学与技术，活动报告，核科学研究设施，化学研究所，京都大学 1。

Kazuo Hiramoto, Junichi Hirota, Tetsurou Norimine, Masatsugu Nishi, Mamoru Katane, Hiroaki Sakurabata, Akira Noda, Yoshihisa Iwashita and Makoto Inoue: "A Compact Proton Synchrotron with a Combined Function Lattice Dedicated for Medical Use" Bulletin of t

Kazuo Hiramoto、Junichi Hirota、Tetsurou Norimine、Masatsugu Nishi、Mamoru Katane、Hiroaki Sakurabata、Akira Noda、Yoshihisa Iwashita 和 Makoto Inoue：“具有专用于医疗用途的组合功能晶格的紧凑型质子同步加速器”公告

A. Noda,Y.Iwashita,M.Inoue,M.Abe.J.Konishi and K.Ono: "Dedicated Accelerator Project for Proton Therapy at Kyoto University" Proceedings of PTCOG XXI Meeting Chiba,Japan November,1994. (in print).

A. Noda、Y.Iwashita、M.Inoue、M.Abe.J.Konishi 和 K.Ono：“京都大学质子治疗专用加速器项目”PTCOG XXI 会议记录，日本千叶，1994 年 11 月。