Mechanisms of long-term regulation of blood pressure by the central nervous system

中枢神经系统长期调节血压的机制

• 批准号: 06670057
• 负责人: NISHIDA Yasuhiro
• 金额: $ 1.28万
• 依托单位: Kagawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670057/
• 关键词: 24-hr-blood pressure; long-term control; Central Nervous System; Area Postrema; Neurohumoral Interaction; Body Fluid Balance; Vasopressin; Arterial Baroreflex; 血圧; ナトリウム嗜好性

Project 1. The purpose of this study is to examine whether the neurohumoral interaction at the area postrema (AP) could function to regulate arterial pressure in a long-term fashion. Vasopressin (0.25 ng/kg/min) was infused for 5 days to the AP-lesioned rabbits (APX) and the intact rabbits (INT), and then compared its effects on sodium and water balances, plasma Na concentration (PNa), plasma osmolality (Posm), mean arterial pressure (MAP), and heart rate (HR) using a metabolic cage. The balance study showed that sodium (Na) and water were hypotonically retained in INT,while not in APX.The data of PNa and Posm supported this result. No significant difference was observed in MAP between the two groups. Bradycardia was observed in INT but not in APX.No significant difference was observed in plasma vasopressin concentration between the two groups. Histological examinations using a Nissl staining method showed that the AP was completely destroyed but the major portions of the nucleus tract … More us solitarius and the dorsal motor nucleus of the vagus and the entire hypoglossal nucleus were intact. These results indicate that the neurohumoral interaction at the AP functions to enhance the water retention action of vasopressin and suppress HR in a long-term fashion, but is not strong enough to overcome other compensatory systems regulating MAP.Project 2. Next, we examined whether the arterial baroreflex system can control MAP in a long-term fashion during physical movements. We established the measuring and analyzing system for 24-hr MAP and compared the histograms of 24-hr MAP between intact and sinoaortic denervated (SAD) rabbits. No significant difference was observed in a mode of MAP during a resting phase between the two groups. However, during a moving phase, SAD abolished an increase in a mode of 24-hr MAP which was observed in intact rabbits. This result leads to the possibility that the central nervous system may contribute to a long-term regulation of MAP during physical movements via the baroreflex system. Less

项目1。本研究的目的是研究脑后区（AP）的神经体液相互作用是否能长期调节动脉压力。采用代谢笼法，将加压素（0.25 ng/kg/min）连续输注于ap损伤兔（APX）和正常兔（INT） 5 d，比较其对钠和水平衡、血浆钠浓度（PNa）、血浆渗透压（Posm）、平均动脉压（MAP）和心率（HR）的影响。平衡研究表明，钠（Na）和水在INT中低渗保留，而在apx中不低渗保留，PNa和Posm的数据支持这一结果。两组间MAP无明显差异。两组间血浆抗利尿激素浓度差异无统计学意义（p < 0.05）。Nissl染色组织学检查显示，AP被完全破坏，但核束的主要部分未见损伤，更多的孤立肌、迷走神经背侧运动核和整个舌下核未见损伤。这些结果表明，AP的神经体液相互作用可以增强抗利尿激素的保水作用，并长期抑制HR，但不足以克服其他调节MAP的代偿系统。项目2。接下来，我们研究了动脉压反射系统是否可以在身体运动过程中长期控制MAP。我们建立了24小时MAP测量分析系统，比较了完整和去神经化（SAD）家兔24小时MAP直方图。两组在静息期的MAP模式无显著差异。然而，在运动阶段，SAD消除了在完整家兔中观察到的24小时MAP模式的增加。这一结果表明，中枢神经系统可能通过压力反射系统参与身体运动过程中MAP的长期调节。少

项目成果

Nishida, Y.: "Neuro-humoral interaction by vasopressin and angiiotensin" Jpn.J.Circ.Res.17(in Japanese). 55-64 (1994)

Nishida, Y.：“加压素和血管紧张素的神经体液相互作用”Jpn.J.Circ.Res.17（日语）。

Nishida, Y., Sugimoto, I., Mizohata, N., Morita, H., and Hosomi, H.: "The baroreflex system is important for determining mean arterial pressure (MAP) during movements" J.Auton.Nerv.Syst. 58. 222-224 (1996)

Nishida, Y.、Sugimoto, I.、Mizohata, N.、Morita, H. 和 Hosomi, H.：“压力反射系统对于确定运动期间的平均动脉压 (MAP) 非常重要” J.Auton.Nerv.Syst

Yasuhiro Nishida: "The baroreflex system is important for determining mean arterial pressure (MAP) during movements." J.Auton.Nerv.Syst.583. 222-224 (1996)

Yasuhiro Nishida：“压力反射系统对于确定运动过程中的平均动脉压 (MAP) 非常重要。”

Yasuhiro Nishida: "The baroreflex system is important for determining mean arterial pressure (MAP) during movements." J.Auton.Nerv.Syst.58 3. 222-224 (1996)

Yasuhiro Nishida：“压力反射系统对于确定运动过程中的平均动脉压 (MAP) 非常重要。”

西田育弘: "バゾプレッシンおよびアンギオテンシンによる神経一体液統合機構" 血管. 17. 55-64 (1994)

Ikuhiro Nishida：“加压素和血管紧张素的神经液整合机制”血管。 17. 55-64 (1994)