Research on free radical on acute mesenteric ischemia and intestinal viability.

自由基对急性肠系膜缺血及肠道活力的研究。

基本信息

  • 批准号:
    06671252
  • 负责人:
  • 金额:
    $ 1.28万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1994
  • 资助国家:
    日本
  • 起止时间:
    1994 至 1996
  • 项目状态:
    已结题

项目摘要

The aim of this research is to investigate pathophysiology of acute mesenteric ischemia (AMI), and to establish the judgment for intestinal viability. Experimental studies ; 1) Histological changes after 2-hour mesenteric artery ligation were mostly limited in the mucosal layr, on the other hand, marked congestion, hemorrhage and edema in the submucosal layr were observed in early stage after venous ligation. 2) Acute mesenteric ischemia after 1 or 2-hr SMA or SMV occlusion, following 1-hr reperfusion in rabbits. SMV-group showed a significant fall of blood pressure during SMV occlusion. Local blood flow, assessed by Laser Doppler flowmetry (LDF), of SMV-group were significantly lower than that of SMA-group. 3) LDF was an useful method to judge the intestinal viability both in arterial and venous occlusion. Clinical study ; 17 patients of acute superior mesenteric arterial occlusion (SMAO) and seven of acute superior mesenteric venous thrombosis (SMVT) were analyzed retrospectively. Mean age was 69 in SMAO and 59 in SMVT,and in SMAO,13 cases had histories of cardiovascular diseases. Presenting symptoms were nonspecific, but the onset of SMAO were often sudden, but those of SMVT were insidious. In most cases of SMAO,small and large bowel were diffusely affected, but in SMVT,segmental infarctions of small intestine were characteristic. In SMAO,mortality was 65% and most of the cases died within one month ater operation. In SMVT,mortality was 43% and 2 cases died 6 months after operation due to recurrence of SMVT.Early diagnosis, postoperative intensive care in SMAO and long-term prophylaxis of recurrent thrombosis in SMVT are critical for successful management of AMI.
本研究旨在探讨急性肠系膜缺血(AMI)的病理生理机制,并建立肠存活的判断标准。实验研究;(1)肠系膜动脉结扎后2小时,组织学改变主要局限于粘膜层,而静脉结扎后早期粘膜下层出现明显充血、出血和水肿。2)家兔SMA或SMV闭塞1或2小时后,再灌注1小时后的急性肠系膜缺血。SMV组在SMV阻断期间血压显著下降。激光多普勒血流仪(LDF)显示,SMV组局部血流明显低于SMA组。3)LDF是判断动、静脉阻断后小肠活力的有效方法。临床研究;回顾性分析17例急性上级肠系膜动脉闭塞(SMAO)和7例急性上级肠系膜静脉血栓形成(SMVT)患者的临床资料。SMAO组的平均年龄为69岁,SMVT组的平均年龄为59岁,SMAO组中有13例有心血管疾病史。临床症状无特异性,SMAO多为突发性,SMVT多为隐匿性。SMAO多表现为小肠和大肠的弥漫性梗死,而SMVT则以小肠节段性梗死为特征。SMAO组死亡率为65%,大多数在术后1个月内死亡。SMVT病死率43%,术后6个月死亡2例,早期诊断、SMAO术后加强监护、长期预防SMVT再发血栓是AMI成功治疗的关键。

项目成果

期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ando M.,Ito M.,et al.: "Spontaneous dissecting aneurysm of the main trunk of the superior mesenterlc artery" Surg Today. 25. 468-470 (1995)
Ando M.,Ito M.,et al.:“肠系膜上动脉主干的自发性夹层动脉瘤”今日外科。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
伊藤雅史ほか.: "四肢血行障害の診断と治療,2)慢性動脈閉塞症." 呼吸と循環. 44. 719-724 (1996)
Masashi Ito 等:“肢体血液循环障碍的诊断和治疗,2) 慢性动脉闭塞。” 44. 719-724 (1996)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
三島好雄ほか.: "消化器手術への血管外科の応用,歴史的背景と展望." 手術. 50. 737-744 (1996)
Yoshio Mishima 等:“血管外科在胃肠外科中的应用、历史背景和展望。” 50. 737-744 (1996)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Ando M., Ito M., et al.: "Spontaneous dissecting aneurysm of the main trunk of the superior mesenteric artery : Report of a case." Surg Today. 25. 468-470 (1995)
Ando M.、Ito M. 等人:“肠系膜上动脉主干自发性夹层动脉瘤:病例报告”。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
伊藤雅史ほか.: "閉塞性動脈硬化症のリスクファクターと予後." 日外会誌. 97. 476-480 (1996)
Masashi Ito 等人:“动脉硬化闭塞症的危险因素和预后。”日本盖亚协会杂志 97. 476-480 (1996)
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ITO Masashi其他文献

Estimation of the optimal leaf area index (LAI) of an eggplant canopy based on the relationship between the nighttime respiration and daytime photosynthesis of the lowermost leaves
基于最下部叶片夜间呼吸和白天光合作用之间的关系估算茄子冠层的最佳叶面积指数(LAI)
  • DOI:
    10.1016/j.scienta.2022.111525
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    NOMURA Koichi;ITO Masashi;KUSABA Yusuke;SAITO Masahiko;MORI Makito;YAMANE Shinzo;IWAO Tadashige;TADA Ikunao;YAMAZAKI Tomihiro;KITANO Masaharu
  • 通讯作者:
    KITANO Masaharu

ITO Masashi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ITO Masashi', 18)}}的其他基金

A speaker identity perception for formant-suppressed vowels
共振峰抑制元音的说话人身份感知
  • 批准号:
    24650137
  • 财政年份:
    2012
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
A perceptual model of speech based on real-time speaker adaptation
基于实时说话人适应的语音感知模型
  • 批准号:
    21700282
  • 财政年份:
    2009
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
A speech perception model integrating formant theory and whole-spectrum model.
一种融合共振峰理论和全谱模型的语音感知模型。
  • 批准号:
    19700242
  • 财政年份:
    2007
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)

相似海外基金

A New Approach to Vascular Reconstruction using Graphical 3D Printing and Flow Modelling to create personalised precision engineered surgery
使用图形 3D 打印和流动建模进行血管重建的新方法,以创建个性化的精密工程手术
  • 批准号:
    463878
  • 财政年份:
    2022
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Operating Grants
Development of a new experimental model of chronic focal cerebral ischemia and elucidation of hyperperfusion following vascular reconstruction
慢性局灶性脑缺血新实验模型的开发及血管重建后过度灌注的阐明
  • 批准号:
    22K09226
  • 财政年份:
    2022
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Plug and play: an innovative bio-artificial artery for vascular reconstruction
即插即用:用于血管重建的创新生物人工动脉
  • 批准号:
    MR/V029827/1
  • 财政年份:
    2021
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Research Grant
Development of unimolecular nanoparticle-mediated periadventitial drug delivery system for sustained and targeted inhibition of intimal hyperplasia following open vascular reconstruction
开发单分子纳米粒子介导的外膜周围药物递送系统,用于持续和靶向抑制开放血管重建后的内膜增生
  • 批准号:
    10305283
  • 财政年份:
    2020
  • 资助金额:
    $ 1.28万
  • 项目类别:
A Novel Synthetic Vascular Graft Capable of Minimally Invasive Controlled Expansion for Vascular Reconstruction Model
一种新型合成血管移植物,能够微创控制扩张血管重建模型
  • 批准号:
    9914886
  • 财政年份:
    2019
  • 资助金额:
    $ 1.28万
  • 项目类别:
Development of a new experimental model of chronic cerebral ischemia with vascular endothelial impairment and elucidation of hyperperfusion following vascular reconstruction
开发慢性脑缺血伴血管内皮损伤的新实验模型并阐明血管重建后的过度灌注
  • 批准号:
    18K08934
  • 财政年份:
    2018
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of unimolecular nanoparticle-mediated periadventitial drug delivery system for sustained and targeted inhibition of intimal hyperplasia following open vascular reconstruction
开发单分子纳米粒子介导的外膜周围药物递送系统,用于持续和靶向抑制开放血管重建后的内膜增生
  • 批准号:
    9481524
  • 财政年份:
    2017
  • 资助金额:
    $ 1.28万
  • 项目类别:
Development of unimolecular nanoparticle-mediated periadventitial drug delivery system for sustained and targeted inhibition of intimal hyperplasia following open vascular reconstruction
开发单分子纳米粒子介导的外膜周围药物递送系统,用于持续和靶向抑制开放血管重建后的内膜增生
  • 批准号:
    9177485
  • 财政年份:
    2016
  • 资助金额:
    $ 1.28万
  • 项目类别:
Development and assessment of a natural bio scafold for vascular reconstruction
用于血管重建的天然生物支架的开发和评估
  • 批准号:
    7834484
  • 财政年份:
    2009
  • 资助金额:
    $ 1.28万
  • 项目类别:
Vascular Reconstruction in Avascular Area of Diabetic Retinopathy
糖尿病视网膜病变无血管区的血管重建
  • 批准号:
    21791722
  • 财政年份:
    2009
  • 资助金额:
    $ 1.28万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了