Experimental Study on Thrombosis of Aneurysms with Cellulose Acetate Polymer

醋酸纤维素聚合物动脉瘤血栓形成的实验研究

• 批准号: 07457318
• 负责人: NAKASHIMA Hiroyuki
• 金额: $ 4.1万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457318/
• 关键词: CELLULOSE ACETATE POLYMER; CEREBRAL ANEURYSM; INTERVENTIONAL NEURORADIOLOGY; DETACHABLE COIL; ENDOVASCULAR NEUROSURGERY

To verify the usefulness of a new embolic material, cellulose acetate polymer (CAP), we performed following experimental studies.(1) Twenty-four experimental canine lateral wall aneurysms were thrombosed with a CAP solution. Angiography performed 1 to 4 weeks after CAP injection revealed complete thrombosis of the aneurysms with patency of the parent artery in 16 aneurysms. Histological analysis disclosed the aneurysmal orifice was completely covered with newly formed endothelial cells 2 weeks after CAP thrombosis.Time until complete reendothelialization was shorter than that described in reports with other embolic materials.(2) We created 9 canine carotid bifurcation aneurysms, which were intentionally partially thrombosed with CAP solution. Follow-up angiograms of 7 aneurysms without crescent crevice between the CAP mass and the aneurysmal sac revealed no shifts of the positions of the CAP masses. The other two aneurysms with significant crescent crevice showed marked enlargement of … More the remnants. Histologically, 7 aneurysms without enlarged remnant had a newly developed endothelium between the aneurysmal lumen and the CAP mass.Partial thrombosis with the CAP solution could prevent regrowth, unless crescent crevice had been left.(3) We used interlocking detachable coils (IDCs) for creating an intraaneurysmal frame. We created 11 canine cervical carotid bifurcation aneurysms. Complete thrombosis was attempted in six cases and intentionally partial thrombosis in five cases. Direct thrombosis of the aneurysm with IDC and CAP was performed. The follow-up angiography was performed 1,2,4 and 8 weeks after thrombosis. In the complete thrombosis group, all aneurysms were successfully thrombosed. Aneurysmal enlargement, however, was demonstrated in two of partial thrombosis group. There were no compaction of IDC-CAP complex.This method can be a new useful technique for the treatment of cerebral aneurysms.Our studies demonstrated that CAP solution is a safe and useful embolic material for thrombosis of aneurysms. Less

为了验证一种新的栓塞材料，醋酸纤维素聚合物（CAP）的有效性，我们进行了以下实验研究。(1)用CAP溶液对24只实验性犬侧壁动脉瘤进行血栓形成。CAP注射后1 ~ 4周行血管造影显示16个动脉瘤完全血栓形成，载瘤动脉通畅。组织学检查显示CAP血栓形成后2周，血管口完全被新生的内皮细胞覆盖，完全再内皮化的时间比其他栓塞材料的报道短。(2)我们创建了9只犬颈动脉分叉部动脉瘤，故意用CAP溶液部分血栓形成。7例冠状动脉瘤瘤体与动脉瘤囊之间无新月形裂隙，随访时冠状动脉瘤体位置无移位。另外两个有明显新月形裂隙的动脉瘤显示明显的 ...更多信息 残余的。组织学上，7个无扩大残余物的动脉瘤在动脉瘤腔和CAP肿块之间有新生内皮，CAP溶液部分血栓形成可防止再生长，除非已留下新月形裂隙。(3)我们使用联锁可解脱弹簧圈（IDC）创建一个颅内框架。我们创建了11只犬颈动脉分叉部动脉瘤。在6例病例中尝试完全血栓形成，在5例病例中故意部分血栓形成。采用IDC和CAP直接栓塞动脉瘤。分别于血栓形成后1、2、4、8周行血管造影随访。在完全血栓形成组中，所有动脉瘤均成功血栓形成。部分血栓组2例出现动脉瘤样扩张。结果表明，CAP溶液是一种安全、有效的动脉瘤栓塞材料。少

项目成果

Sugiu K,Kinugasa K,Mandai S,Tokunaga K,Ohmoto T: "Direct thrombosis of experimental aneurysms with cellulose acetate polymer (CAP) -Its technical aspects, angiographic follow-up, and histological study-." J Neurosurg. 83. 531-538 (1995)

Sugiu K、Kinugasa K、Mandai S、Tokunaga K、Ohmoto T：“醋酸纤维素聚合物 (CAP) 实验性动脉瘤的直接血栓形成 - 其技术方面、血管造影随访和组织学研究 -”。

中嶋 裕之: "Early treatment of subarachuoid hemoruhage after preventing rehptre of an aneurysm" Journal of Neurosurgery. 83. 34-41 (1995)

Hiroyuki Nakajima：“预防动脉瘤后蛛网膜下腔出血的早期治疗”《神经外科杂志》83. 34-41 (1995)。

杉生 憲志: "Direct thrombosis of experimental aneurysms with cellulose acetate polymer (CAP): technical aspects angiograply cal follow up and histoboial study" Journal of Neurosurgery. 83. 531-538 (1995)

Kenji Sugiu：“醋酸纤维素聚合物 (CAP) 实验性动脉瘤的直接血栓形成：血管造影随访和组织学研究的技术方面”《神经外科杂志》83. 531-538 (1995)。

Kinugasa K,Mandai S,Kamata I,Tokunaga K,Sugiu K,Handa A,Nakashima H,Ohmoto T: "Prophylactic thrombosis to prevent new bleeding and delay aneurysm surgery." Neurosurgery. 36. 661-667 (1995)

Kinugasa K、Mandai S、Kamata I、Tokunaga K、Sugiu K、Handa A、Nakashima H、Ohmoto T：“预防性血栓形成，以防止新出血并延迟动脉瘤手术。”

Tokunaga K,Kinugasa K,Mandai S,Handa A,Hirotsune N,Ohmoto T: "Partial thrombosis of canine carotid bifurcation aneurysms with cellulose acetate polymer." Neurosurgery. (in press).

Tokunaga K、Kinugasa K、Mandai S、Handa A、Hirotsune N、Ohmoto T：“醋酸纤维素聚合物引起的犬颈动脉分叉动脉瘤的部分血栓形成。”