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Medical application of Polymer Electrolyte Complek to reconstruction of the alveoler bone and dental implant.

聚合物电解质Complek在牙槽骨和牙种植体重建中的医学应用。

基本信息

批准号：
07457476
负责人：
SHIBA Akihiko
金额：
$ 4.99万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

The pur pose of this study is to, using a new material, Polymer Electrolyte Complex reconstruct a new bone tissue into the suppor ting alveolar bone around teeth absor bed in a process of aging and some diseases and shorten a period which requires the fusion of a bone tissue with a dental implant.We first prepared 90 different PEC membranes, using 6 kinds of polycations and 15 polyanions. Eight promising materials of all the PEC membranes were selected for further experiments from the results of cell-to-cell adhesion tests and proliferation assays of osteogenic, periodontal and epithelial cells as weii as ALP and collagen synthetic activities of osteogenic cells.Two materials of the eight PEC membranes, all of which showed a good in vivo affinity, were found to have an excellent osteoacutis from the results of the in vivo implantation experiment in which the two membranes hybridized with PEC or HA were embeddedinto bones.The in vivo implantation experiment also revealed that the two dental implants coated with the PEC materials could induce significantly more rapid bone formation than the control implants. These dental implants, when used as a carrier substance for BMP,also induced the ectopic osteogenesis. This indicates that they could be used as a carrier. These observations show that the two PEC substances could be useful for bone defect filling and coating dental implants. Thus, these substances are promising new materials that would be put into medical practice.

本研究的目的是利用新材料聚合物电解质复合物在衰老和某些疾病过程中将新的骨组织重建到牙齿吸收床周围的支撑牙槽骨中，并缩短骨组织与牙种植体融合的时间。我们首先使用6种聚阳离子和15种聚阴离子制备了90种不同的PEC膜。根据成骨细胞、牙周细胞和上皮细胞的细胞间粘附试验和增殖测定结果，以及成骨细胞的 ALP 和胶原合成活性，选择所有 PEC 膜中的 8 种有前途的材料进行进一步的实验。 8 种 PEC 膜中的两种材料均表现出良好的体内亲和力，被发现具有优异的骨锐性能。体内植入实验的结果显示，两种与PEC或HA杂交的膜被嵌入骨骼中。体内植入实验还表明，两种涂有PEC材料的牙种植体可以比对照种植体诱导更快的骨形成。这些牙种植体当用作 BMP 的载体物质时，也会诱导异位成骨。这表明它们可以用作载体。这些观察结果表明，这两种 PEC 物质可用于骨缺损填充和牙科植入物涂层。因此，这些物质是有希望应用于医疗实践的新材料。