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Medical application of Polymer Electrolyte Complek to reconstruction of the alveoler bone and dental implant.

聚合物电解质Complek在牙槽骨和牙种植体重建中的医学应用。

基本信息

批准号：
07457476
负责人：
SHIBA Akihiko
金额：
$ 4.99万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

The pur pose of this study is to, using a new material, Polymer Electrolyte Complex reconstruct a new bone tissue into the suppor ting alveolar bone around teeth absor bed in a process of aging and some diseases and shorten a period which requires the fusion of a bone tissue with a dental implant.We first prepared 90 different PEC membranes, using 6 kinds of polycations and 15 polyanions. Eight promising materials of all the PEC membranes were selected for further experiments from the results of cell-to-cell adhesion tests and proliferation assays of osteogenic, periodontal and epithelial cells as weii as ALP and collagen synthetic activities of osteogenic cells.Two materials of the eight PEC membranes, all of which showed a good in vivo affinity, were found to have an excellent osteoacutis from the results of the in vivo implantation experiment in which the two membranes hybridized with PEC or HA were embeddedinto bones.The in vivo implantation experiment also revealed that the two dental implants coated with the PEC materials could induce significantly more rapid bone formation than the control implants. These dental implants, when used as a carrier substance for BMP,also induced the ectopic osteogenesis. This indicates that they could be used as a carrier. These observations show that the two PEC substances could be useful for bone defect filling and coating dental implants. Thus, these substances are promising new materials that would be put into medical practice.

本研究的目的是利用一种新型材料--聚合物电解质复合体，在牙齿老化和某些疾病的过程中，将一种新的骨组织重建为支持牙床周围的牙槽骨，缩短骨组织与牙种植体融合的时间。从成骨细胞、牙周和上皮细胞的细胞间黏附实验和细胞增殖实验以及成骨细胞的碱性磷酸酶和胶原合成活性等方面筛选出了8种材料用于进一步的实验。体内植入实验结果表明，8种材料中的2种材料具有良好的体内亲和力，两种材料与PEC或HA杂化植入骨中。体内植入实验还表明，两种被PEC材料包覆的种植体能够明显促进骨形成。这些种植体作为骨形态发生蛋白的载体材料，也能诱导异位成骨。这表明它们可以被用作载体。这些观察结果表明，这两种PEC物质可用于骨缺损填充和涂层牙种植体。因此，这些物质是很有希望投入医疗实践的新材料。