Synthetic Study on Taxol.

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Paclitaxl has received much attention because of its high cytotoxicity and strong antitumor activity. An increased social demand for paclitaxl prompts us to establish a total synthetic method for paclitaxl. However, the complicated structure of paclitaxl obstructs an efficient route to paclitaxl. So, development of a more readily available paclitaxl analogues will be anticipated in the near future. From these points, we projected an efficient and flexible total synthetic method for paclitaxl. First, racemic A ring synthon was prepared in 10 steps from 2,2-dimethy1-1,3-cyclohexanedione. Second, C ring synthon was synthesized in 12 steps from R-(-)-carvone. A vinyl anion generated from A ring synthon was uneventfully reacted with an aldehyde derived from C ring synthon. However, ring closure of the B ring precursor thus obtained has not been realized yet.