Uncovering the transgenerational dimension of ageing

揭示衰老的跨代维度

• 批准号: DP220101436
• 负责人: Prof Russell Bonduriansky
• 金额: $ 31.45万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101436
• 关键词: Uncovering; transgenerational; dimension; ageing

Despite over a century of research on the biology of ageing, one intriguing aspect of ageing – the widely observed tendency for older parents to produce offspring with reduced lifespan and fitness – remains poorly understood. Such effects could be a major source of variation in individual fitness, could play a role in the evolution of ageing, and could impact human health. Building on recent discoveries by CI Bonduriansky’s research group and others, this project’s aims will address significant questions about the mechanisms mediating these effects, the roles of mothers vs. fathers, and the role of the ambient environment. This project will also contribute new theory on the evolutionary implications of such effects.

尽管对衰老生物学进行了一个多世纪的研究，但衰老的一个有趣方面——广泛观察到的高龄父母生育的后代寿命和健康状况都较差的趋势——仍然知之甚少。这种影响可能是个体健康差异的主要来源，可能在衰老的演变中发挥作用，并可能影响人类健康。在CI Bonduriansky的研究小组和其他人最近的发现的基础上，这个项目的目标是解决有关调解这些影响的机制、母亲与父亲的角色以及周围环境的角色的重要问题。该项目还将为这种影响的进化含义提供新的理论。