Application of anti-washout type fast-setting calcium phosphate cement for the reconstruction of jaw bone

从骨组织反应的角度评价抗冲洗型快速固化磷酸钙骨水泥(Aw-FSCPC)，以探讨其在口腔颌面外科、整形外科和重建外科中临床应用的可行性。因此，在本研究中，我们将Aw-FSCPC植入到实验动物造成的骨缺损中，并以传统的CPC(c-CPC)为对照材料，观察其组织学反应。AW-FSCPC对骨组织的组织反应类似于c-CP。术后2周，骨水泥与新骨之间无纤维性软组织介入，新骨形成，呈桥梁状。随着种植时间的延长，新生骨的数量增加。在骨水泥与软组织的界面处，c-CPC呈细小颗粒散在分布于皮肤组织内，周围可见大量异物巨细胞，而Aw-FSCPC周围有较薄的纤维组织，炎症反应轻微，异物巨细胞较少。也就是说，Aw-FSCPC对软组织表现出了良好的组织响应。我们认为Aw-FSCPC具有良好的临床应用价值，因为它具有较快的固化速度和较高的早期机械强度，以及良好的骨传导性和良好的生物相容性，在口腔颌面外科、整形和重建外科中具有广泛的临床应用价值。

Anti-washout-type fast-setting calcium phosphate cement (aw-FSCPC) was evaluated in terms of bone tissue response to investigate its feasibility for its clinical use in oral and maxillofacial, plastic, and reconstructive surgery. In this investigation, therefore, aw-FSCPC was implanted into bone defects made in experimental animals, and its tissue response was examined histopathologically using conventional CPC (c-CPC) as control materials. aw-FSCPC showed excellent tissue response toward bone tissues similar to c-CPC.New bone, like a bridge, was formed along the cement in the bone marrow and no fibrous soft tissue intervened between the cement and new bone 2 weeks after surgery. The amount of new bone was increased with implantation time. At the interface between cement and soft tissue, small particles of c-CPC had been scattered in the cutaneous tissue and many foreign-body giant cells were collected around the scattered c-CPC.In contrast, aw-FSCPC was surrounded by thin fibrous tissue with slight inflammatory response and few foreign-body giant cell was observed. Namely, aw-FSCPC showed excellent tissue response toward soft tissues. We conclude that aw-FSCPC have good potential value for its use in wider clinical applications in oral and maxillofacial, plastic and reconstructive surgery, since it shows faster setting and higher mechanical strength in the early period that are required in these surgical procedures as well as good osteoconductivity and excellent biocompatibility.