Study on factors that transcriptionally regulate the gene encoding an immunodominant antigen expressed specifically in larval stage of Dirofilaria immitis.

恶丝虫幼虫期特异表达的免疫显性抗原编码基因转录调节因子的研究。

• 批准号: 07670274
• 负责人: SUGANE Kazuo
• 金额: $ 1.41万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670274/
• 关键词: Dirofilaria immitis; immunodominant antigen; promoter; Dirotilaria immitis; 犬糸状虫; 抗原遺伝子; 遺伝子発現

We characterized the genes (Dg2 and DgK) encoding an immunodominant antigen expressed specifically in larval stage of Dirofilaria immitis, and analyzed the function of promoter region of the gene. Microinjection study using Caenorhabditis elegans, the DgK might be expressed only in digestive tract of the nematode.

我们鉴定了编码免疫优势抗原的基因(DG2和DGK)，并分析了该基因启动子区域的功能。利用秀丽线虫的显微注射研究表明，DGK可能只在线虫的消化道中表达。