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Evaluation method of screening for the highly-sensitive subjects of airway allergy by using flow-volume pattern analysis (RAT-FEV1%diagram)

评估%20方法%20of%20筛选%20针对%20%20高度敏感%20受试者%20of%20气道%20过敏%20by%20使用%20流量%20模式%20分析%20（RAT-FEV1%图）

基本信息

批准号：
07670466
负责人：
MEGURO Tadamichi
金额：
$ 1.47万
依托单位：
Kinki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

In 1995, one hundred and fifty middleaged workers were examined pulmonary function tests and total serum IgE level. The data of 16 nonnsmokers and 46 smokers of them were analyzed between the relation of RAT-FEV1% diagram and the level of total serum IgE.Distribution of A-line in RAT-FEV1% diagram were higher than those in B-line in the group of less than 100IU/ml of IgE.Distribution of B-line in the diagram were higher than those in A-line in the group of greater than 100 IU/ml of IgE.In the experiment of 1996, the data of 705 male middle-aged workers more than 35 years old were analyzed between the relation of RAT-FEV1% diagram and the level of total serum IgE.In the experiment of 1997, the data of 1177 male middleaged workers (442 nonsmokers and 735 smokers) more than 35 years old were analyzed between the relation of biological lines of RAT-FEV1% dia-gram (A-, B-, SA-, and SB-line) and the level of total serum IgE.Similar reults were obtained in the two experients.Thus, the results In 1997 were shown in this report. In nonsmokers, the distribution of A-line and SA-line were both 63.3% and 58.8%, but the distributions were 34.2% and 34.5% in B-, and SB-line, in the group, less than 100 IU/ml of total serum IgE level. The distribution was different among A- and SA-line on the one hand and B- and SB-line on the other . (x2=28.21). In smokers, the distributions of A-line and SA-line were both 48.5% and 61.5%, but the distributions were 28.3% and 25.7% in B-, and SB-line, in the group, less than 100 IU/ml of total serum IgE level. The distribution was different among A- and SA-line on the one hand and B-and SB-line on the other. (x2=45.44). Further, in the group of greater than 100 IU/ml of IgE level, the distribution showed a remarkable increase in B-and SB-line (71.4% and 74.3%). Finally, RAT-FEV1% diagram has a meaningful significance in the primary screening method for the highly-sennsitive group of airway allergy.

1995年对150名中年工人进行了肺功能和血清总IgE检测。本文分析了16例非吸烟者和46例吸烟者的RAT-FEV_1%图与血清总IgE水平的关系，结果表明：在血清总IgE <100 IU/ml组，RAT-FEV_1%图中A线分布高于B线分布;在血清总IgE> 100 IU/ml组，RAT-FEV_1%图中B线分布高于A线分布;在血清总IgE <100 IU/ml组，RAT-FEV_1%图中A线分布高于B线分布。1996年对705名35岁以上的中年男性工人进行了RAT-FEV_（1%）图与血清总IgE水平关系的分析，1997年进行了血清总IgE水平与RAT-FEV_（1%）图关系的分析，1177名中年男性工人的资料本文分析了35岁以上非吸烟者442例和吸烟者735例的RAT-FEV_（1%）曲线的生物学线之间的关系结果表明，两次实验的结果基本一致，故本文以1997年的结果为依据。在不吸烟者中，血清总IgE <100 IU/ml者，A系和SA系分别占63.3%和58.8%，而B系和SB系分别占34.2%和34.5%。A系和SA系与B系和SB系之间的分布不同。(x2=28.21）。吸烟者血清总IgE <100 IU/ml时，A线和SA线分别占48.5%和61.5%，而B线和SB线分别占28.3%和25.7%。A系和SA系与B系和SB系之间的分布不同。(x2=45.44）。在IgE水平大于100 IU/ml的组中，B系和SB系的分布显著增加（71.4%和74.3%）。RAT-FEV 1%图在气道过敏高敏组的初筛方法中具有一定的意义。