Study on oncoimmunology in carrier children of HTLV-I

我们调查了人类t淋巴细胞病毒I型（HTLV-I）从母亲到孩子的传播12年。结果表明：1)htlv - 1的母婴传播率在奶瓶喂养者中为4.9%，在母乳喂养者中为8.0%。在母乳喂养者中，7个月以上母乳喂养儿童组的传播率高于6个月以下母乳喂养儿童组（25.0%对2.5%）。两组间的传播率差异有统计学意义。2)出生后6个月左右检测到母亲携带的抗htlv - 1抗体，提示对htlv - 1垂直感染具有防御作用。3) htlv - 1感染组的可溶性白细胞介素-2受体水平高于htlv - 1携带者未感染组和正常对照组。但由于两组接受测试的儿童数量较少，因此两组之间没有明显差异。4)需要进一步的研究，如对HTLV-I感染和人类白细胞抗原（HLA）在HTLV-I携带母亲所生儿童中的免疫学研究。

We have investigated the transmission of human T-lymphotropic virus type I (HTLV-I) from mother-to-child for 12 years. The results are follows :1)Transmission of HTLV-I from mother-to-child occurred with the rate of 4.9% in bottle feeders, and 8.0% in breast feeders. Among breast feeders, the rate of transmission was higher in the group of more than 7 months breast-fed children than in the group of less than 6 months brestfed children (25.0% vs 2.5%). There was statistically significant differences in the rate of trans-mission between the two groups.2)Anti-HTLV-I antibody transmitted from mother, which have been detected by about 6 months after birth, was suggested to act as defensive against HTLV-I vertical infection.3)The level of soluble interleukin-2 receptor was higher in the group of HTLV-I transmitted children than that in the group of non-transmitted children born to HTLV-I carrier mothers, and that in the group of normal control children. But no significant differences was admitted between the groups, due to small numbers of children tested in those groups.4)Further investigations such as immunological studies against HTLV-I infection and human leukocyte antigens (HLA) among children born to HTLV-I carrier mothers are needed.