A case-control study on alcohol drinding habit, ALDH2 genotype and colorectal cancer.

饮酒习惯、ALDH2基因型与结直肠癌的病例对照研究

• 批准号: 07807043
• 负责人: MURATA Motoi
• 金额: $ 1.47万
• 依托单位: CHIBA CANCER CENTER RESEARCH INSTITUTE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07807043/
• 关键词: colorectal cancer; alcohol drinking habit; ALDH2 genotype

A case-control study was conducted to explore a possible etiological role of alcohol drinking habit in colorectal cancer. Cases were 243 colon and 147 rectum cancer patients who were surgically treated in Chiba Cancer Center Hospital during the period 1989 through 1997. Controls were 1,124 persons including both patients of benign diseases and attendants of a health check program. Information on their life styles such as drinking, smoking and dietary habits was collected by a self-administered questionnaire. For a part of them (210 cases and 303 controls), alcohl tolerance was also checked by a DNA test of ALDH2 genotypes with the PCR method. Japanese population shows inter-individual variation of aldehyde dehydrogenase activity due to a polymorphism of this gene, with alcohol tolerant 1/1 homozygotes, intermediate 1/2 heterozygotes and intolerant 2/2 homozygotes.According to a uni-variate analysis with the chi-square statistical test, the factors such as daily amount of alcohol consumption, frequent intake of meat, and irregular, hastened and excess meal habits were all significantly associated with both colon and rectum cancers, whereas infrequent intake of milk and fish was associated only with rectum cancer. Daily amount of tobacco smoked, intake frequency of fruits and vegetables were not different between cases and controls. These results remained unchanged even after a multi-variate logistic regression analysis was performed. If the ALDH2 genotype was included in the multi-variate analysis, this genotype instead of alcohol consumption showed signficant association with colon cancer, indicating that reduced enzyme activity in the heterozygotes is a risk factor for colon cancer. This is most prominent for sigmoid colon cancer. No such relation was found for rectum cancer. It is concluded that excess alcohl drinking is a risk factor for colorectal cancer and that the heterozygotes of ALDH2 are especially a high-risk group for colon cancer.

采用病例对照研究方法，探讨饮酒习惯在大肠癌发病中的作用。病例为1989年至1997年期间在千叶癌症中心医院接受手术治疗的243名结肠癌患者和147名直肠癌患者。对照组为1,124人，包括良性疾病患者和健康检查计划的参与者。通过自填问卷收集他们的生活方式，如饮酒、吸烟和饮食习惯。对其中210例患者和303例对照者进行了ALDH 2基因型检测。日本人群乙醛脱氢酶活性存在个体间差异，表现为耐酒精1/1纯合子、耐酒精1/2杂合子和不耐酒精2/2纯合子。进食过快和过量的饮食习惯与结肠癌和直肠癌都有显著的相关性，而不经常摄入牛奶和鱼只与直肠癌有关。每日吸烟量、水果和蔬菜摄入频率在病例组和对照组之间无差异。即使在进行多变量logistic回归分析后，这些结果仍保持不变。如果ALDH 2基因型包括在多变量分析中，则该基因型而不是饮酒与结肠癌显着相关，表明杂合子中酶活性降低是结肠癌的风险因素。这在乙状结肠癌中最为突出。而直肠癌则无此关系。结论过量饮酒是大肠癌的危险因素，ALDH 2杂合子是大肠癌的高危人群。

项目成果

Motoi Murata et al.: "A nested case-control study on alcohol drinking,tabacco smoking,and cancer." Cancer Detect.& Prev. 20. 557-565 (1996)

Motoi Murata 等人：“一项关于饮酒、吸烟和癌症的巢式病例对照研究。”

Murata, M., Takayama, K., Choi, BCK.and Pak, AWP.: "Anested case-control study on alcohol drinking, tobacco smoking, and cancer." Cancer Detect.& Prev.20 (6). 557-565 (1996)

Murata, M.、Takayama, K.、Choi, BCK. 和 Pak, AWP.：“饮酒、吸烟和癌症的麻醉病例对照研究”。

Motoi Murata et al.: "Analysis of a germline polymorphism of tje p53 gene in lung cancer patients;discrete results with smoking history." Carcinogenesisi. 17(2). 261-264 (1996)

Motoi Murata 等人：“肺癌患者 tje p53 基因种系多态性分析；与吸烟史的离散结果。”

Motoi Murata et al.: "A nested case-control study on alcohol drinking,tabacco smoking,and cancer." Cancer Detect.& Prev.20. 557-565 (1996)

Motoi Murata 等人：“一项关于饮酒、吸烟和癌症的巢式病例对照研究。”

Motoi Murata et al.: "Analysis of a germ line polymorphism of the p53 gebe in lung cancer patients; discrete results with smoking history." Carcinogenesis. 17. 261-264 (1996)

Motoi Murata 等人：“肺癌患者 p53 gebe 种系多态性分析；与吸烟史相关的离散结果。”