Changes in masticatory movements and motor neuronal activities after lesioning of the tongue projection area of the first somatosensory cortex in awake cats.

清醒猫第一体感皮层舌头投影区受损后咀嚼运动和运动神经元活动的变化。

• 批准号: 07838039
• 负责人: HIRABA Hisao
• 金额: $ 1.34万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07838039/
• 关键词: the first somatosensory cortex Sl); mastication-related neuron (MRN); lesioned cats of the perioral projection area (PL-cats); lesioned cats of the tongue projection area (TL-cats); motor cortex (MC : areas M,P and C); changes in orofacial behaviors

We have studied activity patterns and properties of mastication-related neurons (MRNs) in the orofacial first somatosensory (Sl) and motor (MC : M,P and C) cortices of awake cats. Most MRNs in Sl, M,P and C Had common receptive fields in perioral or tongue regions. Over 90% of MRNs in Sl showed activity changes following the masticatory rhythm (Post-movement RB). Over 50% of MRNs in M showed sustained activities (Pre-movement SB) before and during masticatory movements. About 40% of MRNs in P showed activity changes before movements of the jaw and tongue (Pre-movement TB). About 50% of MRNs in C were Post-movement RB.To investigated the function of the perioral or tongue projection area of Sl, we examined changes in orofacial behaviors and activities of MRNs in MC for 5-6 weeks after lesioning by a kainic acid injection (0.1%, 2mul) into the perioral or tongue projection area (PL and TL-cats). In the early phase (for 10 days after a lesion), PL-cats showed a delay in the masticatory start and a drop of food from mouth. TL-cats showed prolongations of the ingestion time. The proportion of MRNs with receptive fields in the perioral region of PL-cats was reduced by 70% in M,P and C in comparison with norma cats. MRNs with receprive fields in the tongue of TL-cats were not recorded in P.PL-cats decreased Pre-movement SB rate in M and Post-movement RB rate in C.TL-cats decreased Pre-movement TB rate in P.These findings suggest that perioral or tongue information in Sl during mastication may transfer commands of continuous contractions around the mouth or of appropriate movements following food condition to M or P.

本文研究了清醒猫口面第一躯体感觉皮层（S1）和运动皮层（MC：M、P和C）咀嚼相关神经元（MRN）的活动模式和特性。S1、M、P和C的MRN多数在口周或舌区有共同的感受野。在S1中超过90%的MRN显示出咀嚼节律（运动后RB）后的活动变化。超过50%的MRN在咀嚼运动之前和期间显示持续活动（运动前SB）。大约40%的MRN在下颌和舌头运动之前（运动前TB）显示活动变化。C组中约50%的MRN为运动后RB。为了研究S1口周或舌投射区的功能，我们观察了口周或舌投射区注射0.1%红藻氨酸（kainic acid，2 μ l）后5-6周MC中MRN的口面行为和活动变化。在早期阶段（病变后10天），PL-猫表现出咀嚼开始延迟和食物从口中掉落。TL猫的摄入时间延长。PL猫口周区MRN与感受野的比例在M、P和C中比正常猫减少了70%。PL猫减少运动前SB率在M和运动后RB率在C. TL猫减少运动前TB率在P.这些研究结果表明，口周或舌头的信息在S1咀嚼过程中可能会转移命令的口周围的连续收缩或适当的运动后的食物条件下的M或P。

项目成果

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Mori, A., Fuwa, T., Kawai, A., Yoshimoto, T., Hiraba, H., Uchiyama, Y.and Minejima, T.: "The ipsilateral and contralateral connections of the fifth somatosensory area (SV) in the cat cerebral cortex." NeuroReport. 7. 2385-2387 (1996)

Mori, A.、Fuwa, T.、Kawai, A.、Yoshimoto, T.、Hiraba, H.、Uchiyama, Y. 和 Minejima, T.：“第五体感区 (SV) 的同侧和对侧连接

森昭雄: "The ipsilateral and contralateral connections of the fifth somatosensory area (SV) in the cat cerebral cortex." Neuroreport. 7・14. 2385-2387 (1996)

Akio Mori：“猫大脑皮层第五体感区（SV）的同侧和对侧连接。” Neuroreport 7・14（1996）。