Behavioral and neurochemical studies of schizophrenia using an animal model of the phychosis.

反复服用甲基苯丙胺会导致人类出现精神分裂样窒息，并导致动物的行为敏感化。对行为敏感化的理解可能有助于了解甲基苯丙胺诱导的窒息和精神分裂症的发病机制。1)在小笼子里重复接受甲基苯丙胺的大鼠没有表现出运动活动的增强，但表现出刻板行为的增强，这表明环境改变了行为敏化的表达。2)M胆碱能受体的拮抗剂东莨菪碱阻止了行为敏化的发生。中枢胆碱能受体似乎在行为敏感化的发展中起作用。3)氯硝西潘和中枢GABA-苯二氮卓类受体的激动剂，可阻止行为敏感化。中枢GABA神经传递似乎在行为敏化的发展中起作用。这些结果与谷氨酸拮抗剂和蛋白质合成抑制剂也阻止敏化的报道相结合，可能表明行为敏化与学习和记忆等其他神经可塑性变化具有一些共同的性质。

Repeated administration of methamphetamine results in schizophrenia-like phychosis in human and behavioral sensitization in animals. Understanding of behavioral sensitization may provide insight into the pathogenesis of both methamphetamine-induced phychosis and schizophrenia.1) Rats repeatedly received methamphetamine in a small cage did not show enhancement in locomotoer activity but showed enhancement in stereotyped behavior, suggesting that environment modifies the expression of behavioral sensitization.2) Scopolamine, an antagonist of muscarinic cholinergic receptors, prevented behavioral sensitization. Central cholinergic receptors seem to play a role in the development of behavioral sensitization.3) Clonazepam, and agonist of central GABA-benzodiazepine receptors, prevented behavioral sensitization. Central GABA neurotransmission seems to play a role in the development of behavioral sensitization.These results, taken together with the reports showing glutamate antagonists and protein synthesis inhibitors also prevent sensitization, may indicate that behavioral sensitization have some common properties with other neural plastic change such as learning and memory.