Analysis of apo E-gene abnormality in lipoprotein glomerulopathy

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Lipoprotein glomerulopathy (LPG) is a rare renal disease characterized by proteinuria, lipoprotein thrombi in the glomeruli and increased concentration of plasma apolipoprotein E^<1.2)>. We analyzed apo E abnormality in 6 patients of LPG from 5 families. We found a new variant of apolipoprotein E (E Sendai) with a proline residue substituted for an arginine residue at position 145. All patients were heterozygous for this variant. The 4 carriers of apo E Sendai were found in KO and MI families. One of them was treated for chronic renal failure. The histological examination had not been done, and the diagnosis was not clarified. Our results suggest that apo E Sendai may be etiologically related to lipoprotein glomerulopathy.