Splanchnic perfusion following open-heart surgery

心脏直视手术后的内脏灌注

• 批准号: 07671451
• 负责人: ISHIKAWA Susumu
• 金额: $ 1.6万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671451/
• 关键词: Splanchnic perfusion; Open-heart surgery; Cardiopulmonary bypass; Gastric intramucosal pH; Hepatic venous oxygen saturation

To determine splanchnic perfusion after cardiopulmonary bypass, gastric intramucosal pH (pHi) and hepatic venous oxygen saturation (S_<HV>O_2) were measured in patients following open-heart surgery. Blood samples were analyzed at 6,12 and 24 hours after the admission to an intensive care unit (ICU). The results were as follows : 1)Gastric pHi increased significantly (p<0.01) from 7.21 at 6 hours to 7.31 at 12 hours and recovered to 7.37 at 24 hours, 2)S_<HV>O_2 increased significantly (p<0.05) from 48% at 6 hours to 57% at 12 hours and 24 hours, and 3)cardiac index was more than 4 L/min/m^2 and mixed venous oxygen saturation was over 70%. Despite sufficient cardiac output, splanchnic perfusion decreased after cardiopulmonary bypass and it recovered within 24 hours afrer admission to an ICU.In conclusion, gastric pHi and S_<HV>O_2 are useful parameters for postoperative splanchnic perfusion in patients with open-heart surgery.

为了解体外循环后内脏灌注情况，测定了心脏直视手术后胃粘膜pH（pHi）和肝静脉血氧饱和度（S_<HV>O_2）。在进入重症监护室（ICU）后6、12和24小时分析血液样品。结果表明：（1）胃pH值由6 h的7.21显著升高（P&lt;0.01），12 h为7.31，24 h恢复到7.37;（2）S_<HV>O_2显著升高（P&lt;0.01）（p&lt;0.05）从6小时的48%到12小时和24小时的57%，3）心脏指数大于4 L/min/m^2，混合静脉血氧饱和度大于70%。体外循环后，尽管心输出量充足，但内脏灌注仍明显下降，并在进入ICU后24小时内恢复正常。结论：胃pH值和S_<HV>O_2是心内直视手术病人术后内脏灌注的有用指标。

项目成果

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