Morphological and functional study of endothelium in implanted free graft

带蒂胸内动脉(ITA)具有良好的远期通畅性，已成为冠状动脉旁路移植术(CABG)的首选管道。然而，在大多数情况下，冠状动脉旁路移植术需要多次冠状动脉重建，因此，对杂种家犬游离动、静脉移植物的形态和功能进行了体内研究，并对移植物的通畅性和冠状动脉旁路移植术后的远期疗效进行了临床研究。静脉移植物(VG)内皮细胞在植入后脱落，并在植入后3周再生，而动脉移植物(AG)内皮细胞无明显变化。在功能方面，移植后早期VG的前列环素产量均低于AG。1996年，VG的晚期形态和功能变化…更多的研究是在平均接受移植物植入9.8个月的杂种中进行的。晚期AG全部通畅，移植静脉通畅率为70%。在形态上，AG内的内皮细胞保存完好，而VG内的内皮细胞很少见内皮细胞的粘连，在功能上VG的前列环素的产生在晚期低于AG。1995和1996年，270个大隐静脉和28个AG作为游离移植物，206个AG作为原位移植物CAB。术后心脏无死亡发生率和心脏事件发生率，多动脉导管组明显好于SVG组。我们的实验研究表明，植入AG后在形态和功能上的优势可能是CABG术后晚期临床效果良好的部分原因。较少

Use of the pedicled internal thoracic artery (ITA) has become well established as a first choice of graft conduit for coronary artery bypass grafting (CABG) in ischemic heart disease (IHD) because of the good long-term patency of the graft. However, in most cases, multiple coronary revascularization are required for CABG and thus, morphology and function of free arterial and vein graft of mongrel are studies in vivo and also graft patency of arterial and vein graft and late result after CABG are clinically studied.In 1995 early morphological and functional changes were studied in autologous free femoral arterial and vein graft of mongrel. The endothelium of the vein graft (VG) detached after implantation and regenerated until 3 weeks after implantation, while no significant changes occurred in the arterial graft (AG). In function, the production of prostacylin of VG was lower than that of AG in any early phase after transplantation.In 1996 the late morphological and functional changes … More were studied in the mongrel which had been received graft implantation for an average of 9.8 months. In late period, the AG was patent in all, while the patency rate of the vein graft was 70%. Morphologically the endothelial cell in AG was well preserved, while the endothelial cell was rarely detected with an adhesion of platelet-like materials in the VG.Functionally the production of prostacyclin of prostacyclin was lower in VG than that of AG in late period.In 1995 and 1996,270 saphenous vein grafts and 28 AG were used as free grafts and 206 AG were used as in situ graft CABG.Early postoperative patency of the graft was similar in each graft, however, in late follow-up period, postoperative cardiac death free rate and cardiac event free rate were better in patients with multiple arterial conduit than those with SVG.The morphological and functional superiority of the AG after implantation seen in our experimental studies seemed contribute in a part to the good clinical results in late periods after CABG. Less