The relationship between the carcinoma of the tongue and the muscle by 3D imageing.

通过 3D 成像观察舌癌与肌肉之间的关系。

• 批准号: 07672186
• 负责人: TAKAKI Takashi
• 金额: $ 1.41万
• 依托单位: TOKYO DENTAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672186/
• 关键词: carcinoma of the tongue; growth pattern; tongue muscle; three dimentional imaging; ヒト舌扁平上皮癌; 腫瘍の浸潤方向

This study removed primary squamous-cell carcinoma on the lingual margin, and visualized the sequential samples from the border area between the tumor and host as computerized three-dimensional reconstructed images to examine how the progress forms of various tumors with different invasion mechanisms are related to the intrinsic lingual muscle direction at the progress site.The tumors invaded into the lingual muscular tunics in three modes : invasion of the tumor alveolar structure with interstitial tissues, which presses muscular fibrous fascicles (Type 1), diffuse invasion of the tumor into the pores of the muscular fibrous fascicles with or without the funicular, alveolar structure formed by the tumor (Type 2), and the invasion of the tumor into muscular fibrous fascicles (Type 3).The tumors showing the Type 1 progress mode showed no relation between tumor progress form and intrinsic lingual muscle direction. Type 1 was observed in both the type 2 and 3 invasion modes, which indicates that tumors with limited invasion tend to follow the Type 1 progress mode. The tumors showing the Type 2 progress mode irregularly invaded the pores of the muscular fibrous fascicles. Some of them progressed in the same direction as that of the superficial lingual muscle. Type 2 was observed in the type 4C and 4d invasion modes, indicating that tumors with high invasion tend to follow the Type 2 progress mode. Tumors showing the Type 3 progress mode indicated that small masses consisting of the tumor cells and interstitial tissues progressed in the same direction as that of the muscular fibers in the muscular fibrous fascicles. Type 3 was observed in type 4D invasion, which suggests a relation to invasion intensity.An examination of the excision area showed that a uniform safety zone around the tumor would be necessary for Type 1. For Type 2 and 3, a wider safety zone in the direction of the lingual muscle would be necessary because the tumor tends to progress in that direction.

本研究切除舌缘原发鳞状细胞癌，并将肿瘤与宿主交界处的连续标本可视化为计算机三维重建图像，以观察各种不同侵袭机制的肿瘤的进展形式与进展点固有的舌肌方向的关系。肿瘤以三种方式侵袭舌肌层：肿瘤以间质组织侵袭肿瘤的肺泡结构，压迫肌肉纤维束(类型1)，肿瘤弥漫性侵袭肌肉纤维束的毛孔(类型2)，肿瘤形成的肺泡结构(类型2)，肿瘤向肌纤维束的侵袭(3型)。呈1型进展模式的肿瘤进展形式与固有舌肌方向无关。在2型和3型侵袭模式中都观察到了1型，这表明侵袭性有限的肿瘤倾向于遵循1型进展模式。呈II型进展模式的肿瘤不规则地侵犯肌纤维束的毛孔。其中一些与舌浅肌肉的进展方向相同。在4C型和4D型侵袭模式中观察到2型，提示高侵袭性肿瘤倾向于遵循II型进展模式。呈3型进展模式的肿瘤表明，由肿瘤细胞和间质组织组成的小肿块与肌纤维束中的肌纤维进展方向相同。在4D侵袭型中观察到3型，这表明这与侵袭强度有关。对切除区域的检查表明，对于1型，肿瘤周围需要一个统一的安全区。对于2型和3型，由于肿瘤倾向于向舌肌方向发展，需要在舌肌方向上有更宽的安全区。